Inflammation modifies status epilepticus-induced hippocampal injury during development.
Inflammation modifies status epilepticus-induced hippocampal injury during development.
复制标题
炎症会改变发育过程中癫痫持续状态引起的海马损伤。
DOI：
10.1111/j.1528-1167.2007.01338.x
复制
发表时间：
2007
期刊：
影响因子：
5.6
通讯作者：
Mazarati,Andrey
中科院分区：
文献类型：
--
作者：
Sankar,Raman;Auvin,Stéphane;Shin,Don;Mazarati,Andrey
The relationship between seizures and neuronal injury in experimental animals is influenced by the stage of development and the model employed to produce experimental status epilepticus (SE)(Sankar et al., 1997; Sankar et al., 1998; Sankar et al., 2000; Cilio et al., 2003). In these experimental models, younger animals show a decreased tendency to demonstrate neuronal injury, especially in the CA3 and hilar regions of the hippocampus (Sanker et al., 1997; Sanker et al., 1998; Sankar et al., 2000; Cilio et al., 2003; Haas et al., 2001). However, P14 animals showed a striking level of CA1 injury in the lithium-pilocarpine model of SE.There is an apparent discrepancy between animal models and some clinical situations in terms of the consequences of prolonged seizures in the immature brain. Prolonged febrile seizures have been demonstrated to produce signal changes in the MRI that are consistent with hippocampal injury (VanLandingham et al., 1998). Neuronal injury in neonates who had sustained hypoxic-ischemic was more severe when the encephalopathy was complicated by seizures (Miller et al., 2002). The developmental outcome of neonates with electrographic seizures was worse than that of a cohort without seizures even though the two groups were matched for Apgar scores, initial cord blood pH, and base deficits (McBride et al., 2000). Seizures in these clinical settings occurred when inflammation was already present, an aspect not reproduced in animal studies pertaining to the effect of seizures on the developing brain.
