Gain, Preservation, and Loss of a Group 1a Coronavirus Accessory Glycoprotein
Gain, Preservation, and Loss of a Group 1a Coronavirus Accessory Glycoprotein
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DOI：
10.1128/jvi.01031-08
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发表时间：
2008-10-01
影响因子：
5.4
通讯作者：
de Groot, Raoul J.
中科院分区：
文献类型：
--
作者：
Lorusso, Alessio;Decaro, Nicola;de Groot, Raoul J.
冠状病毒是一种正链RNA病毒，具有非凡的遗传复杂性和多样性。除了一组共同的复制酶基因和结构蛋白外，每个冠状病毒可能携带多个明显通过相对较新的异源重组事件获得的群特异性基因。在这里，我们描述了犬冠状病毒I型(CCoV-I)特有的辅助基因ORF3，并对其产物糖蛋白GP3进行了鉴定。ORF3在CCoV-I中保守，而在CCoV-II和CCoV-II衍生的猪和猫冠状病毒中只有残基。我们的发现为了解冠状病毒1a组的进化史和辅助基因的获得和丢失的动态提供了洞察力。
Coronaviruses are positive-strand RNA viruses of extraordinary genetic complexity and diversity. In addition to a common set of genes for replicase and structural proteins, each coronavirus may carry multiple group-specific genes apparently acquired through relatively recent heterologous recombination events. Here we describe an accessory gene, ORF3, unique to canine coronavirus type I (CCoV-I) and characterize its product, glycoprotein gp3. Whereas ORF3 is conserved in CCoV-I, only remnants remain in CCoV-II and CCoV-II-derived porcine and feline coronaviruses. Our findings provide insight into the evolutionary history of coronavirus group 1a and into the dynamics of gain and loss of accessory genes.