High-dose antioxidant supplements and cognitive function in community-dwelling elderly women
High-dose antioxidant supplements and cognitive function in community-dwelling elderly women
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DOI：
10.1093/ajcn/77.4.975
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发表时间：
2003-04-01
影响因子：
7.1
通讯作者：
Willett, WC
中科院分区：
文献类型：
--
作者：
Grodstein, F;Chen, J;Willett, WC
背景：实验数据表明氧自由基可能参与了认知过程的恶化。目的：我们的目标是研究大剂量抗氧化剂补充剂与认知的关系。设计：从1980年开始，通过邮寄问卷从参与护士健康研究的14968名社区居住妇女中收集有关含有维生素E和C的特定补充剂使用情况的信息。从1995年到2000年，对当时年龄在70-79岁的女性进行了认知功能的电话测试[认知状态(TICS)电话访谈，TICS 10个单词列表的延迟回忆，一小段的即刻和延迟回忆，言语流畅性测试，以及数字广度倒推测试]。我们使用线性和Logistic回归模型来计算特定补充剂使用者与不使用维生素C的人的测试分数的多变量调整平均差异和低分数的相对风险。结果：长期来看，目前服用维生素E和维生素C的人的平均表现明显好于从未使用维生素E或C的女性(P=0.03)；随着使用时间的增加，平均分数有越来越高的趋势(P=0.04)。这些关联在饮食中α-生育酚摄入量较低的女性中最强。单独服用维生素E的女性的益处不太一致，没有证据表明使用时间越长得分越高。单独使用特定的维生素C补充剂与我们的认知测试中的表现几乎没有关系。结论：使用特定的维生素E补充剂，而不是特定的维生素C补充剂，可能与老年女性的适度认知益处有关。
Background: Experimental data suggest that oxygen free radicals are probably involved in the deterioration of cognitive processes.Objective: Our objective was to investigate the relation of high-dose antioxidant supplements to cognition.Design: Information on the use of specific supplements containing vitamins E and C was collected biennially via mailed questionnaires beginning in 1980 from 14 968 community-dwelling women who participated in the Nurses' Health Study. From 1995 to 2000, telephone tests of cognitive function [Telephone Interview of Cognitive Status (TICS), delayed recall of the TICS 10-word list, immediate and delayed recall of a short paragraph, a test of verbal fluency, and a digit span backwards test] were administered to the women, who were 70-79 y of age at that time. We used linear and logistic regression models to calculate multivariate-adjusted mean differences in test scores and relative risks of a low score for specific supplement users compared with nonusers.Results: Long-term, current users of vitamin E with vitamin C had significantly better mean performance, as judged by a global score that combined individual test scores, than did women who had never used vitamin E or C (P = 0.03); there was a trend for increasingly higher mean scores with increasing durations of use (P = 0.04). These associations were strongest among women with low dietary intakes of alpha-tocopherol. Benefits were less consistent for women taking vitamin E alone, with no evidence of higher scores with longer durations of use. Use of specific vitamin C supplements alone had little relation to performance on our cognitive tests.Conclusion: The use of specific vitamin E supplements, but not specific vitamin C supplements, may be related to modest cognitive benefits in older women.