Vitamin D receptor signaling mechanisms: integrated actions of a well-defined transcription factor.
Vitamin D receptor signaling mechanisms: integrated actions of a well-defined transcription factor.
复制标题
维生素 D 受体信号传导机制：明确转录因子的综合作用。
DOI：
10.1016/j.steroids.2012.10.019
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发表时间：
2013-02
期刊：
影响因子：
2.7
通讯作者：
Campbell MJ
中科院分区：
文献类型：
--
作者：
Carlberg C;Campbell MJ
维生素D最具生物活性的代谢物1α，25-二羟基维生素D3 （1α,25(OH)2D3）的主要生理作用是钙和磷的吸收和运输，从而控制骨的形成。1α,25(OH)2D3作用的其他新兴领域是控制免疫功能，细胞生长和分化。1α,25(OH)2D3的所有基因组作用都是由转录因子维生素D受体（VDR）介导的，自20世纪80年代以来，VDR一直是研究的重点。因此，维生素D信号主要暗示了VDR的分子作用。在这篇综述中，我们从不同的角度介绍了VDR，包括它作为转录因子和核受体超家族成员的作用，它在全基因组位置和DNA结合模式上的动态变化，它与染色质组分及其主要蛋白质编码和非蛋白质编码靶基因的相互作用，以及这些方面如何在调控网络中统一起来。通过比较VDR（一种相对了解和表征的蛋白质）与其他转录因子的作用，我们的目标是在其他细胞内信号系统的背景下建立维生素D信号的现实定位。
The main physiological actions of the biologically most active metabolite of vitamin D, 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1α,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. All genomic actions of 1α,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980’s. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this review, we present different perspectives on the VDR that incorporate its role as transcription factor and member of the nuclear receptor superfamily, its dynamic changes in genome-wide locations and DNA binding modes, its interaction with chromatin components and its primary protein-coding and non-protein coding target genes and finally how these aspects are united in regulatory networks. By comparing the actions of the VDR, a relatively well-understood and characterized protein, with those of other transcription factors, we aim to build a realistic positioning of vitamin D signaling in the context of other intracellular signaling systems.