Therapeutic effects of clenbuterol in a murine model of amyotrophic lateral sclerosis.
Therapeutic effects of clenbuterol in a murine model of amyotrophic lateral sclerosis.
复制标题
克伦特罗在肌萎缩侧索硬化症小鼠模型中的治疗作用。
DOI：
10.1016/j.neulet.2005.12.007
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发表时间：
2006
影响因子：
2.5
通讯作者：
Sabharwal,Sunil
中科院分区：
文献类型：
--
作者：
Teng,YangD;Choi,Howard;Huang,Wenzheng;Onario,RennaC;Frontera,WalterR;Snyder,EvanY;Sabharwal,Sunil
We investigated the effects of clenbuterol, a β2-adrenoceptor agonist with known anabolic and neuroprotective properties, on G93A-SOD1 mice, a transgenic murine model of familial amyotrophic lateral sclerosis (ALS). Relative to saline-treated vehicle controls (0.2ml/kg/day; i.p.), early pathologic G93A-SOD1 mice treated with clenbuterol (1.5mg/kg/day; i.p.) demonstrated a delayed onset of hindlimb signs as measured by rotarod performance, slowed disease progression, as well as trends toward mitigated losses of lumbar motoneurons and body weight. Responses in female G93A-SOD1 mice were favorable to those of males, suggesting synergistic effects between clenbuterol and sex-specific factors. Overall, our data suggest that clenbuterol offers therapeutic effects on ALS-related neuromuscular degeneration.
