Optical imaging of temporal integration in human auditory cortex.
Optical imaging of temporal integration in human auditory cortex.
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人类听觉皮层时间整合的光学成像。
DOI：
10.1111/j.1460-9568.2006.05255.x
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Gratton,Gabriele
中科院分区：
文献类型：
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作者：
Sable,JeffreyJ;Low,KathyA;Whalen,ChristopherJ;Maclin,EdwardL;Fabiani,Monica;Gratton,Gabriele
行为和生理研究表明存在听觉整合时间窗口（TWI），相似的声音在感知上被分组。目前的研究利用快速光学成像（事件相关光学信号，EROS）的组合时间和空间分辨率来表明 TWI 内外的声音引起的大脑活动在位置和延迟方面存在差异。在之前的一项事件相关脑电位 (ERP) 研究中 [Sable, Gratton, and Fabiani (2003)European Journal of Neuroscience, 17, 2492–2496]，我们发现，当异常的 SOA 在 TWI 内时，刺激起始异步 (SOA) 偏差引起的失配负性（MMN；大脑对声学不规则性的反应）具有独特的形状。在本研究中，我们使用 EROS 扩展了这些 ERP 结果。参与者听到了五种声音的声音。前四个音调的 SOA 为 96、192、288 或 384ms。第四个和第五个音调的 SOA 要么是相同的（标准），要么是其他三个（异常）SOA 之一。当异常 SOA 为 96 毫秒时，皮质反应比对较长 SOA 异常的反应早大约 2 厘米，随后是其他条件下不存在的较晚的反应。与电 MMN 类似，光学失配响应幅度与间隔偏差的大小成正比。这些结果与我们之前的发现相结合，表明声音的时间整合反映在皮质不匹配反应中，该反应不同于对间隔偏差的典型反应。
Behavioral and physiological studies have indicated the existence of a temporal window of auditory integration (TWI), within which similar sounds are perceptually grouped. The current study exploits the combined temporal and spatial resolution of fast optical imaging (the event‐related optical signal, EROS) to show that brain activity elicited by sounds within and outside the TWI differs in location and latency. In a previous event‐related brain potential (ERP) study [Sable, Gratton, and Fabiani (2003)European Journal of Neuroscience, 17, 2492–2496], we found that the mismatch negativity (MMN; a brain response to acoustic irregularities) elicited by deviations in stimulus onset asynchronies (SOAs) had a unique shape when the deviant SOA was within the TWI. In the present study, we extended these ERP results using EROS. Participants heard trains of five tones. The first four tones had SOAs of 96, 192, 288 or 384 ms. The SOA of the fourth and fifth tones was either the same (standard) or one of the other three (deviant) SOAs. With a deviant SOA of 96 ms, the cortical response was approximately 2 cm anterior to responses to longer SOA deviants, and was followed by a later response that was absent in the other conditions. Similarly to the electrical MMN, the optical mismatch response amplitudes were proportional to the magnitude of interval deviance. These results, in combination with our previous findings, indicate that the temporal integration of sounds is reflected in cortical mismatch responses that differ from the typical response to interval deviance.