Unexpected and pronounced antinociceptive synergy between spinal acetaminophen (paracetamol) and phentolamine.
Unexpected and pronounced antinociceptive synergy between spinal acetaminophen (paracetamol) and phentolamine.
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脊髓对乙酰氨基酚（扑热息痛）和酚妥拉明之间具有意想不到的明显的抗伤害协同作用。
DOI：
10.1016/s0014-2999(01)00722-1
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发表时间：
2001
影响因子：
5
通讯作者：
Tallarida,RJ
中科院分区：
文献类型：
--
作者：
Raffa,RB;StoneJr,DJ;Tallarida,RJ
对乙酰氨基酚单独或与酚妥拉明（11.3 μg=0.03 μmol）给药小鼠。对乙酰氨基酚在腹部刺激试验中产生剂量相关的抗痛作用，ed50值为137.2 μg （0.9 μmol）。酚妥拉明没有效果。联合给药时，对乙酰氨基酚的效价显著提高（ED50=24.4 vs. 137.2 μg），表明两者具有倍增相互作用和较强的协同作用。这些结果揭示了脊髓肾上腺素能受体或离子通道亚型与对乙酰氨基酚诱导的抗痛觉作用的显著和令人惊讶的相互作用。
Acetaminophen was administered to mice by spinal (intrathecal, i.t.) injection alone or with phentolamine (11.3 μg=0.03 μmol). Acetaminophen produced dose-related antinociception in the abdominal irritant test with an ED50value of 137.2 μg (0.9 μmol). Phentolamine had no effect. For combined administration, the potency of acetaminophen was significantly increased (ED50=24.4 vs. 137.2 μg), indicative of multiplicative interaction and strong synergism. These results reveal the significant and surprising interaction of spinal cord adrenoceptors or ion channel subtypes with acetaminophen-induced antinociception.