Schizophrenia Imaging Signatures and Their Associations With Cognition, Psychopathology, and Genetics in the General Population.
Schizophrenia Imaging Signatures and Their Associations With Cognition, Psychopathology, and Genetics in the General Population.
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DOI：
10.1176/appi.ajp.21070686
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发表时间：
2022-09
影响因子：
17.7
通讯作者：
Davatzikos, Christos
中科院分区：
文献类型：
--
作者：
Chand, Ganesh B.;Singhal, Pankhuri;Dwyer, Dominic B.;Wen, Junhao;Erus, Guray;Doshi, Jimit;Srinivasan, Dhivya;Mamourian, Elizabeth;Varol, Erdem;Sotiras, Aristeidis;Hwang, Gyujoon;Dazzan, Paola;Kahn, Rene S.;Schnack, Hugo G.;Zanetti, Marcus, V;Meisenzahl, Eva;Busatto, Geraldo F.;Crespo-Facorro, Benedicto;Pantelis, Christos;Wood, Stephen J.;Zhuo, Chuanjun;Shinohara, Russell T.;Shou, Haochang;Fan, Yong;Koutsouleris, Nikolaos;Kaczkurkin, Antonia N.;Moore, Tyler M.;Verma, Anurag;Calkins, Monica E.;Gur, Raquel E.;Gur, Ruben C.;Ritchie, Marylyn D.;Satterthwaite, Theodore D.;Wolf, Daniel H.;Davatzikos, Christos
精神分裂症相关表型在人群水平的患病率和意义在文献中有争议。在这里，作者评估了两个最近报道的精神分裂症的神经解剖学特征--特征1，灰质体积广泛减少，特征2，纹状体体积增加--是否可以在一个独立的精神分裂症样本中复制，并调查了这些特征的表达是否可以在人群水平上检测到，以及它们与认知，精神病谱症状和精神分裂症遗传风险的关系。这项横断面研究使用了一个独立的精神分裂症对照样本（N=347;年龄16-57岁）进行成像特征的复制，然后检查两个独立的人群水平数据集：费城神经发育队列中典型发育中的青年和患有精神病谱系症状的青年（N=359;年龄16-23岁）和英国生物库研究中的成人（N=836;年龄44-50岁）。作者使用支持向量机学习量化签名表达，并比较签名之间的认知，精神病理学和多基因风险。精神分裂症的两个神经解剖学特征被复制。签名1，但不是签名2是显着更常见的青年精神病谱症状比在典型的发展青年，而签名2的频率是相似的两组。在青少年和成年人中，签名1与签名2相比，认知表现更差。与没有签名的成年人相比，表达签名1的成年人精神分裂症多基因风险评分升高，但签名2没有。作者成功地复制了精神分裂症的两个神经解剖学特征，并描述了它们在青年和成人人群样本中的患病率。他们进一步证明了这些特征与精神病症状，认知和遗传风险的独特关系，可能反映了潜在的神经生物学脆弱性。
The prevalence and significance of schizophrenia-related phenotypes at the population level is debated in the literature. Here, the authors assessed whether two recently reported neuroanatomical signatures of schizophrenia—signature 1, with widespread reduction of gray matter volume, and signature 2, with increased striatal volume—could be replicated in an independent schizophrenia sample, and investigated whether expression of these signatures can be detected at the population level and how they relate to cognition, psychosis spectrum symptoms, and schizophrenia genetic risk. This cross-sectional study used an independent schizophrenia-control sample (N=347; ages 16–57 years) for replication of imaging signatures, and then examined two independent population-level data sets: typically developing youths and youths with psychosis spectrum symptoms in the Philadelphia Neurodevelopmental Cohort (N=359; ages 16–23 years) and adults in the UK Biobank study (N=836; ages 44–50 years). The authors quantified signature expression using support-vector machine learning and compared cognition, psychopathology, and polygenic risk between signatures. Two neuroanatomical signatures of schizophrenia were replicated. Signature 1 but not signature 2 was significantly more common in youths with psychosis spectrum symptoms than in typically developing youths, whereas signature 2 frequency was similar in the two groups. In both youths and adults, signature 1 was associated with worse cognitive performance than signature 2. Compared with adults with neither signature, adults expressing signature 1 had elevated schizophrenia polygenic risk scores, but this was not seen for signature 2. The authors successfully replicated two neuroanatomical signatures of schizophrenia and describe their prevalence in population-based samples of youths and adults. They further demonstrated distinct relationships of these signatures with psychosis symptoms, cognition, and genetic risk, potentially reflecting underlying neurobiological vulnerability.
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影响因子：
14.5
作者：
Chand, Ganesh B.;Dwyer, Dominic B.;Davatzikos, Christos
通讯作者：
Davatzikos, Christos
影响因子：
5.7
作者：
Doshi J;Erus G;Ou Y;Resnick SM;Gur RC;Gur RE;Satterthwaite TD;Furth S;Davatzikos C;Alzheimer's Neuroimaging Initiative
通讯作者：
Alzheimer's Neuroimaging Initiative
影响因子：
10.6
作者：
Sanfelici, Rachele;Dwyer, Dominic B.;Koutsouleris, Nikolaos
通讯作者：
Koutsouleris, Nikolaos
影响因子：
3.7
作者：
Gur, Ruben C.;Butler, Ellyn R.;Gur, Raquel E.
通讯作者：
Gur, Raquel E.
影响因子：
11
作者：
Kapur, S.;Phillips, A. G.;Insel, T. R.
通讯作者：
Insel, T. R.