Connectivity-based parcellation reveals distinct cortico-striatal connectivity fingerprints in Autism Spectrum Disorder
Connectivity-based parcellation reveals distinct cortico-striatal connectivity fingerprints in Autism Spectrum Disorder
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DOI：
10.1016/j.neuroimage.2017.02.019
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发表时间：
2018-04-15
期刊：
影响因子：
5.7
通讯作者：
Wenderoth, Nicole
中科院分区：
文献类型：
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作者：
Balsters, Joshua H.;Mantini, Dante;Wenderoth, Nicole
自闭症谱系障碍（ASD）与突触发育异常有关，导致功能连接中断。然而，当使用静息状态fMRI在宏观尺度上测量时，这些改变是微妙的，并且由于病理学的大异质性而通常难以检测。最近，我们概述了一种新的方法，用于产生强大的生物标志物的静息状态功能磁共振成像（RS-fMRI）使用基于连接的分割的总体形态结构，以提高单个主题的再现性，并产生更强大的连接指纹。在这里，我们应用这种新的方法来调查组织和连接强度的皮质-纹状体系统在一个大样本的ASD个体和典型的发达国家（TD）控制（N=130每组）。我们的研究结果表明，在纹状体的包裹在ASD的差异。具体而言，壳核被发现是一个单一的结构在ASD，而这是分为前和后段在年龄，智商和头部运动相匹配的TD组。连接指纹的分析表明，聚类的组差异是由纹状体和辅助运动区，后扣带皮层，后扣带皮层之间的差异连接驱动的。我们在临床人群中分析RS-fMRI的方法提供了明确的证据表明，皮质-纹状体回路在ASD中的组织方式不同。基于以前的任务为基础的分割纹状体，我们认为，前壳核集群存在于TD，但不是在ASD，可能有助于社会和语言过程。
Autism Spectrum Disorder (ASD) has been associated with abnormal synaptic development causing a breakdown in functional connectivity. However, when measured at the macro scale using resting state fMRI, these alterations are subtle and often difficult to detect due to the large heterogeneity of the pathology. Recently, we outlined a novel approach for generating robust biomarkers of resting state functional magnetic resonance imaging (RS-fMRI) using connectivity based parcellation of gross morphological structures to improve single-subject reproducibility and generate more robust connectivity fingerprints. Here we apply this novel approach to investigating the organization and connectivity strength of the cortico-striatal system in a large sample of ASD individuals and typically developed (TD) controls (N=130 per group). Our results showed differences in the parcellation of the striatum in ASD. Specifically, the putamen was found to be one single structure in ASD, whereas this was split into anterior and posterior segments in an age, IQ, and head movement matched TD group. An analysis of the connectivity fingerprints revealed that the group differences in clustering were driven by differential connectivity between striatum and the supplementary motor area, posterior cingulate cortex, and posterior insula. Our approach for analysing RS-fMRI in clinical populations has provided clear evidence that cortico-striatal circuits are organized differently in ASD. Based on previous task-based segmentations of the striatum, we believe that the anterior putamen cluster present in TD, but not in ASD, likely contributes to social and language processes.