Chemical physiology of oxidative stress-activated TRPM2 and TRPC5 channels.
Chemical physiology of oxidative stress-activated TRPM2 and TRPC5 channels.
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氧化应激激活的 TRPM2 和 TRPC5 通道的化学生理学。
DOI：
10.1016/j.pbiomolbio.2010.05.005
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发表时间：
2010
影响因子：
3.8
通讯作者：
Y. Mori
中科院分区：
文献类型：
--
作者：
Shinichiro Yamamoto;N. Takahashi;Y. Mori
感知和适应各种环境变化的能力对所有细胞的生存至关重要。瞬时受体电位（TRP）通道在这些感知和适应反应中起着关键作用。在脊椎动物中，大约有30个TRP通道；根据蛋白质序列的同源性将其分为六个亚家族。我们之前已经揭示了一组TRP通道感知氧化应激并诱导细胞信号传导和基因表达。TRPM2是TRPM亚家族的一员，通过产生第二信使被活性氧（ROS）激活。最近，我们证明了Ca2+内流通过ROS激活的TRPM2诱导单核细胞产生趋化因子，从而加重炎症性中性粒细胞浸润。此外，我们还发现一氧化氮、含有活性二硫化物的化合物和炎症介质通过对半胱氨酸残基的氧化修饰直接激活TRPC、TRPV和TRPA亚家族。在这篇综述中，我们描述了这些TRP通道如何感知氧化应激并诱导适应反应，并讨论了氧化应激激活TRP通道的生物学重要性。
The ability to sense and adapt to a wide variety of environmental changes is crucial for the survival of all cells. Transient receptor potential (TRP) channels play pivotal roles in these sensing and adaptation reactions. In vertebrates, there are about 30 TRP channels; these are divided into six subfamilies by homology of the protein sequences. We have previously revealed that a group of TRP channels senses oxidative stress and induces cellular signaling and gene expression. TRPM2, a member of the TRPM subfamily, is activated by reactive oxygen species (ROS) via second-messenger production. Recently, we demonstrated that Ca2+influx through TRPM2 activated by ROS induces chemokine production in monocytes, which aggravates inflammatory neutrophil infiltration. Additionally, we also revealed that nitric oxide, chemical compounds containing reactive disulfide, and inflammatory mediators directly activate the TRPC, TRPV, and TRPA subfamilies via oxidative modification of cysteine residues. In this review, we describe how these TRP channels sense oxidative stress and induce adaptation reactions, and we discuss the biological importance of oxidative stress-activated TRP channels.
影响因子：
16
作者：
Kolisek, M;Beck, A;Penner, R
通讯作者：
Penner, R