Contrasting patterns of mitochondrial redistribution in the early lineages of Caenorhabditis elegans and Acrobeloides sp. PS1146.
Contrasting patterns of mitochondrial redistribution in the early lineages of Caenorhabditis elegans and Acrobeloides sp. PS1146.
复制标题
秀丽隐杆线虫和Acrobeloides sp的早期谱系中线粒体重新分布的对比模式。
DOI：
10.1016/s0012-1606(03)00102-7
复制
发表时间：
2003
影响因子：
2.7
通讯作者：
White,JohnG
中科院分区：
文献类型：
--
作者：
Badrinath,AnanthS;White,JohnG
我们比较了秀丽隐杆线虫（C. elegans）和Acrobeloides sp. PS1146 （Acrobeloides）两种线虫的早期胚胎中线粒体的再分配，这两种线虫的胚胎轴规范机制不同，尽管随后的发育非常相似（Goldstein et al., 1998）。在秀丽隐杆线虫的第一个细胞周期中，线粒体随着朝向精子原核的大量细胞质流动而移动，并在称为“假卵裂”的时期聚集在后皮层。相反，在Acrobeloides胚胎中，没有明显的细胞质重排，最初松散分布在原核周围的线粒体和细胞质在细胞分裂前被重新安置在有丝分裂纺锤体周围。有趣的是，这种重排只在种系中重复，而不是在体细胞谱系中。在这两个物种中，线粒体在细胞分裂前的位置与已知的种系决定因子P颗粒的位置相关，这使我们推测它们可能存在关联。
We compared the redistribution of mitochondria in the early embryos of Caenorhabditis elegans (C. elegans) and Acrobeloides sp. PS1146 (Acrobeloides)—two nematode species where the mechanisms for embryonic axis specification are different even though subsequent development is remarkably similar (Goldstein et al., 1998). During the first cell cycle of C. elegans, mitochondria move with the bulk cytoplasmic flows that are directed toward the sperm pronucleus and aggregate at the posterior cortex during the period known as “pseudocleavage.” In contrast, in Acrobeloides embryos, where prominent cytoplasmic rearrangements are absent, mitochondria that are initially distributed loosely around the pronuclei and the cytoplasm are relocated around the mitotic spindle prior to cell division. Interestingly, this rearrangement is reiterated only in the germline and not the somatic lineage. In both species, the location of the mitochondria immediately prior to cell division correlates with the known location of the germline determinants, P granules, leading us to speculate that they may be associated.