High-resolution STM imaging of novel poly(G)-poly) DNA molecules
High-resolution STM imaging of novel poly(G)-poly) DNA molecules
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DOI：
10.1021/jp0569638
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发表时间：
2006-03-09
影响因子：
3.3
通讯作者：
Porath, D
中科院分区：
文献类型：
--
作者：
Shapir, E;Cohen, H;Porath, D
高分辨率扫描隧道显微镜（STM）成像的单双链聚（G）-聚（C）DNA分子，由一种新的合成方法，显示了分子形态。STM图像揭示了类似于4 nm的周期性结构，被视为沿着分子沿着重复的“灯泡”。这些“灯泡”与分子螺旋（主要凹槽）有关。沿着DNA也观察到平均每100 nm两个“切口”。的STM测量支持的DNA分子的沟槽长度和相对于表面的表观高度的形态统计。
High-resolution scanning tunneling microscopy (STM) imaging of single double-stranded poly(G)-poly(C) DNA molecules, made by a novel synthesis method, shows the molecules morphology. The STM images reveal a periodic structure of similar to 4 nm, seen as repeating "bulbs" along the molecules. These "bulbs" are associated with the molecule helix (the major grooves). "Nicks", two per 100 nm on the average, are observed along the DNA as well. The STM measurements were supported by a morphological statistics of the DNA molecule groove length and apparent height relative to the surface.