Neospora caninum is the leading cause of bovine fetal loss in British Columbia, Canada.
Neospora caninum is the leading cause of bovine fetal loss in British Columbia, Canada.
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DOI：
10.1016/j.vetpar.2016.01.006
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发表时间：
2016-03-15
影响因子：
2.6
通讯作者：
Raverty SA
中科院分区：
文献类型：
--
作者：
Wilson DJ;Orsel K;Waddington J;Rajeev M;Sweeny AR;Joseph T;Grigg ME;Raverty SA
原生动物病原体犬新孢子虫被认为是世界范围内牛传染性流产的主要原因。为了评估新孢子虫病对奶牛和肉牛生产的影响，在加拿大不列颠哥伦比亚省进行了一项回顾性纵向研究，以确定新孢子虫病与其他胎儿流产原因的影响。回顾性分析2007年1月至2013年7月提交给不列颠哥伦比亚省阿伯茨福德动物卫生中心（一个省级兽医诊断实验室）的牛胎儿病理记录，确定了182例堕胎病例（被动监测）。从2013年7月至2014年5月，一个积极的监测项目在不列颠哥伦比亚省上弗雷泽河谷的奶农中又发现了54例堕胎病例。在分析的236例胎儿中，18.2%的病例被诊断为犬链球菌，使其成为与胎儿丢失相关的最常见的感染因子。在主动监测期间，与13.3%的被动监测相比，犬奈瑟菌与41%的胎儿提交相关（P<0.001）。牛的品种与犬链球菌的诊断显著相关，在奶牛品种中比在牛肉品种中患病率更高，3-6个月胎龄的胎儿中犬链球菌的患病率最高。与大坝平价无显著相关性。除2009年外，每年都诊断出犬新孢子虫，病例在全省地理上广泛分布。此外，主动监测计划表明，犬奈瑟菌在上弗雷泽河谷高度流行，是该乳制品密集地区生产损失的主要原因。
The protozoan pathogen Neospora caninum is recognized as a leading cause of infectious abortions in cattle worldwide. To evaluate the impact of neosporosis on dairy and beef herd production, a retrospective, longitudinal study was performed to identify the impact of neosporosis alongside other causes of fetal abortion in British Columbia, Canada. Retrospective analysis of pathology records of bovine fetal submissions submitted to the Animal Health Centre, Abbotsford, British Columbia, a provincial veterinary diagnostic laboratory, from January 2007– July 2013 identified 182 abortion cases (passive surveillance). From July 2013–May 2014, an active surveillance program identified a further 54 abortion cases from dairy farmers in the Upper Fraser Valley, British Columbia. Of the total 236 fetal submissions analyzed, N. caninum was diagnosed in 18.2% of cases, making it the most commonly identified infectious agent associated with fetal loss. During active surveillance, N. caninum was associated with 41% of fetuses submitted compared to 13.3% during passive surveillance (P<0.001). Breed of dam was significantly associated with N. caninum diagnosis, with a higher prevalence in dairy versus beef breeds, and fetuses of 3–6 months gestational age had the highest prevalence of N. caninum. There was no significant association with dam parity. Neospora caninum was diagnosed in every year except 2009 and cases were geographically widespread throughout the province. Furthermore, the active surveillance program demonstrates that N. caninum is highly prevalent in the Upper Fraser Valley and is a major causal agent of production losses in this dairy intensive region.