Evolution of the brain tumour spheroid model: transcending current model limitations
Evolution of the brain tumour spheroid model: transcending current model limitations
复制标题
脑肿瘤球体模型的演变：超越当前模型的局限性
DOI：
10.1007/s00701-003-0096-0
复制
发表时间：
2003
影响因子：
2.4
通讯作者：
R. D. del Maestro
中科院分区：
文献类型：
--
作者：
A. Corcoran;L. de Ridder;D. Del Duca;O. J. P. Kalala;T. Lah;G. Pilkington;R. D. del Maestro
肿瘤复发以及与恶性脑肿瘤相关的高死亡率和发病率可能归因于当前治疗方式（手术、放疗和化疗）未能控制恶性脑肿瘤细胞侵入健康脑组织。一些体外和体内模型已被开发并用于研究脑肿瘤的侵袭和细胞运动。在这里，我们回顾了一些传统的体外脑肿瘤侵袭模型以及对广泛使用的球体模型的最新适应。几个研究小组通过改进肿瘤迁移和侵袭的体外模型，对脑肿瘤侵袭机制的研究做出了重要贡献。分享这些进步将有望加速实验发现和新型抗侵袭脑肿瘤疗法的发展。
Summary¶Tumour recurrence and the high mortality and morbidity associated with malignant brain tumours may be attributed to the failure of current therapeutic modalities (surgery, radiation and chemotherapy) to control the invasion of malignant brain tumour cells into healthy brain tissue. Several in vitro and in vivo models have been developed and used to study brain tumour invasion and cell motility. Here, we review some of the traditional in vitro models of brain tumour invasion and the latest adaptations to the widely used spheroid model. Several research groups studying the mechanisms mediating brain tumour invasion have made important contributions to the field by improving in vitro models of tumour migration and invasion. Sharing these advances will hopefully accelerate experimental discovery and the development of novel anti-invasion brain tumour therapies.