Fe–Fe Double-Atom Catalysts for Murine Coronavirus Disinfection: Nonradical Activation of Peroxides and Mechanisms of Virus Inactivation
Fe–Fe Double-Atom Catalysts for Murine Coronavirus Disinfection: Nonradical Activation of Peroxides and Mechanisms of Virus Inactivation
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DOI：
10.1021/acs.est.3c00163
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发表时间：
2023-02
影响因子：
11.4
通讯作者：
Zhe Zhou;Mengqiao Li;Yuxin Zhang;Lingchen Kong;V. F. Smith;Mengyang Zhang;Anders J. Gulbrandson;G. Waller;Feng Lin;Xitong Liu;D. Durkin;Hanning Chen;Danmeng Shuai
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作者：
Zhe Zhou;Mengqiao Li;Yuxin Zhang;Lingchen Kong;V. F. Smith;Mengyang Zhang;Anders J. Gulbrandson;G. Waller;Feng Lin;Xitong Liu;D. Durkin;Hanning Chen;Danmeng Shuai
过氧化物广泛应用于消毒环境病原体，特别是在COVID-19大流行中;然而，化学消毒剂的广泛使用可能威胁人类健康和生态系统。为了实现稳健和可持续的消毒，同时将不利影响降至最低，我们开发了Fe单原子和Fe-Fe双原子催化剂，用于活化过一硫酸盐（PMS）。负载在硫掺杂的石墨碳氮化物上的Fe-Fe双原子催化剂的氧化性能优于其他催化剂，并且它可能通过催化剂介导的电子转移的非自由基途径活化PMS。这种Fe-Fe双原子催化剂增强了PMS灭活鼠冠状病毒的消毒动力学（即，小鼠肝炎病毒株A59（MHV-A59））在包括模拟唾液和淡水的多种环境介质中与单独PMS处理相比降低2.17-4.60倍。MHV-A59失活的分子水平的机制也被阐明。Fe-Fe双原子催化不仅促进病毒蛋白质和基因组的破坏，而且促进病毒在宿主细胞中的内化，这是病毒生命周期的关键步骤，从而增强PMS消毒的效力。我们的研究首次推进了双原子催化用于环境病原体控制，并为鼠冠状病毒消毒提供了基本见解。我们的工作为利用先进材料改善消毒、环境卫生和个人卫生习惯以及保护公众健康铺平了新的道路。
Peroxides find broad applications for disinfecting environmental pathogens particularly in the COVID-19 pandemic; however, the extensive use of chemical disinfectants can threaten human health and ecosystems. To achieve robust and sustainable disinfection with minimal adverse impacts, we developed Fe single-atom and Fe–Fe double-atom catalysts for activating peroxymonosulfate (PMS). The Fe–Fe double-atom catalyst supported on sulfur-doped graphitic carbon nitride outperformed other catalysts for oxidation, and it activated PMS likely through a nonradical route of catalyst-mediated electron transfer. This Fe–Fe double-atom catalyst enhanced PMS disinfection kinetics for inactivating murine coronaviruses (i.e., murine hepatitis virus strain A59 (MHV-A59)) by 2.17–4.60 times when compared to PMS treatment alone in diverse environmental media including simulated saliva and freshwater. The molecular-level mechanism of MHV-A59 inactivation was also elucidated. Fe–Fe double-atom catalysis promoted the damage of not only viral proteins and genomes but also internalization, a key step of virus lifecycle in host cells, for enhancing the potency of PMS disinfection. For the first time, our study advances double-atom catalysis for environmental pathogen control and provides fundamental insights of murine coronavirus disinfection. Our work paves a new avenue of leveraging advanced materials for improving disinfection, sanitation, and hygiene practices and protecting public health.