Coupling of pupil- and neuronal population dynamics reveals diverse influences of arousal on cortical processing.
Coupling of pupil- and neuronal population dynamics reveals diverse influences of arousal on cortical processing.
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DOI：
10.7554/elife.71890
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发表时间：
2022-02-08
期刊：
影响因子：
7.7
通讯作者：
Gross J
中科院分区：
文献类型：
--
作者：
Pfeffer T;Keitel C;Kluger DS;Keitel A;Russmann A;Thut G;Donner TH;Gross J
觉醒的波动受皮层下神经调节系统控制，不断塑造皮层状态，对信息处理产生深远影响。然而，到目前为止，唤醒信号如何影响大脑皮层人口活动的细节只被描述为几个选定的大脑区域。传统的解释将觉醒概念化为大脑皮层神经群活动的同质调节性。然而，最近的见解指出，在神经活动的不同组成部分和皮质区域上，唤醒效应具有更高的特异性。在这里，我们提供了一个全面的帐户之间的波动，在觉醒和神经元群体活动之间的关系。利用瞳孔大小和中枢唤醒系统之间已建立的联系，我们在三个实验室中对大量参与者进行了脑磁图（MEG）和瞳孔图同步记录。我们发现了与自发瞳孔扩张的峰值时间相关的级联效应：颞叶和外侧额叶皮层的低频（2 - 8hz）活动减少，其次是额叶中部区域的高频（> - 64hz）活动增加，然后是枕顶区中频范围活动（8 - 32hz）的单调和倒U关系。与瞳孔相关的觉醒也与皮层群体活动的非周期性成分结构的广泛变化相吻合，表明底层微回路中兴奋-抑制平衡的变化。我们的研究结果为研究皮层回路中认知计算的觉醒调节提供了新的基础。
Fluctuations in arousal, controlled by subcortical neuromodulatory systems, continuously shape cortical state, with profound consequences for information processing. Yet, how arousal signals influence cortical population activity in detail has so far only been characterized for a few selected brain regions. Traditional accounts conceptualize arousal as a homogeneous modulator of neural population activity across the cerebral cortex. Recent insights, however, point to a higher specificity of arousal effects on different components of neural activity and across cortical regions. Here, we provide a comprehensive account of the relationships between fluctuations in arousal and neuronal population activity across the human brain. Exploiting the established link between pupil size and central arousal systems, we performed concurrent magnetoencephalographic (MEG) and pupillographic recordings in a large number of participants, pooled across three laboratories. We found a cascade of effects relative to the peak timing of spontaneous pupil dilations: Decreases in low-frequency (2–8 Hz) activity in temporal and lateral frontal cortex, followed by increased high-frequency (>64 Hz) activity in mid-frontal regions, followed by monotonic and inverted U relationships with intermediate frequency-range activity (8–32 Hz) in occipito-parietal regions. Pupil-linked arousal also coincided with widespread changes in the structure of the aperiodic component of cortical population activity, indicative of changes in the excitation-inhibition balance in underlying microcircuits. Our results provide a novel basis for studying the arousal modulation of cognitive computations in cortical circuits.