Could the D614G substitution in the SARS-CoV-2 spike (S) protein be associated with higher COVID-19 mortality?
Could the D614G substitution in the SARS-CoV-2 spike (S) protein be associated with higher COVID-19 mortality?
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DOI：
10.1016/j.ijid.2020.05.071
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发表时间：
2020-07-01
影响因子：
8.4
通讯作者：
Al-Mulla, Fahd
中科院分区：
文献类型：
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作者：
Eaaswarkhanth, Muthukrishnan;Madhoun, Ashraf Al;Al-Mulla, Fahd
COVID-19大流行导致的死亡人数不断增加，引起全球严重关注。检测能力的提高和充足的重症监护可以解释一些国家死亡率低于其他国家的原因。然而，SARS-CoV-2突变引起不同的系统发育分支也是造成世界各地明显死亡率差异的原因。目前缺乏将SARS-CoV-2的遗传组成与死亡率联系起来的研究文献。在这里，我们认为，这种死亡率的差异可能归因于SARS-CoV-2不断演变的突变，并敦促国际社会开始解决与临床结果有关的SARS-CoV-2的系统发育Glade分类。(C)2020作者（S）由爱思唯尔有限公司代表国际传染病学会出版。
The increasing number of deaths due to the COVID-19 pandemic has raised serious global concerns. Increased testing capacity and ample intensive care availability could explain lower mortality in some countries compared to others. Nevertheless, it is also plausible that the SARS-CoV-2 mutations giving rise to different phylogenetic clades are responsible for the apparent death rate disparities around the world. Current research literature linking the genetic make-up of SARS-CoV-2 with fatalities is lacking. Here, we suggest that this disparity in fatality rates may be attributed to SARS-CoV-2 evolving mutations and urge the international community to begin addressing the phylogenetic Glade classification of SARS-CoV-2 in relation to clinical outcomes. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.