Quantitative measurements of Parkinson's disease correlate alternating finger tapping in with UPDRS motor disability and reveal the improvement in fine motor control from medication and deep brain stimulation
Quantitative measurements of Parkinson's disease correlate alternating finger tapping in with UPDRS motor disability and reveal the improvement in fine motor control from medication and deep brain stimulation
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DOI：
10.1002/mds.20556
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发表时间：
2005-10-01
影响因子：
8.6
通讯作者：
Bronte-Stewart, HM
中科院分区：
文献类型：
--
作者：
Tavares, ALT;Jefferis, GSXE;Bronte-Stewart, HM
帕金森氏病统一评定量表(UPDRS)是大多数帕金森氏病(PD)治疗临床试验的主要结果衡量标准。马达部分(UPDRS 111)的每个分值将大范围的马达性能压缩成从0到4的粗粒度等级；对性能的评估也可能是主观的。定量数字成像(QDG)是一种使用计算机接口音乐键盘对数字运动控制进行客观、定量的评估。在这项研究中，我们发现在33名帕金森病患者中，使用QDG的重复交替手指敲击(RAFT)任务的运动学与UPDRS运动评分，特别是与运动迟缓亚分相关。我们发现，多巴胺能药物和平均9.5个月的双侧丘脑底核深部脑刺激(B-STN DBS)显着改善UPDRS和QDG评分，但对某些运动学参数可能有不同的影响。这项研究证实了在帕金森病治疗试验中使用QDG来测量运动结果，并表明药物和B-STN DBS都改善了精细运动控制。(C)2005年运动无序协会。
The Unified Parkinson's Disease Rating Scale (UPDRS) is the primary outcome measure in most clinical trials of Parkinson's disease (PD) therapeutics. Each subscore of the motor section (UPDRS 111) compresses a wide range of motor performance into a coarse-grained scale from 0 to 4; the assessment of performance can also be subjective. Quantitative digitography (QDG) is an objective, quantitative assessment of digital motor control using a computer-interfaced musical keyboard. In this study, we show that the kinematics of a repetitive alternating finger-tapping (RAFT) task using QDG correlate with the UPDRS motor score, particularly with the bradykinesia subscore, in 33 patients with PD. We show that dopaminergic medication and an average of 9.5 months of bilateral subthalamic nucleus deep brain stimulation (B-STN DBS) significantly improve UPDRS and QDG scores but may have different effects on certain kinematic parameters. This study substantiates the use of QDG to measure motor outcome in trials of PD therapeutics and shows that medication and B-STN DBS both improve fine motor control. (c) 2005 Movement Disorder Society.