Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes
Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes
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DOI：
10.1182/blood.v96.6.2240.h8002240_2240_2245
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发表时间：
2000-09-15
期刊：
影响因子：
20.3
通讯作者：
Albitar, M
中科院分区：
文献类型：
--
作者：
Aguayo, A;Kantarjian, H;Albitar, M
血管生成与实体瘤的生长、扩散和转移有关。本研究的目的是评估急慢性白血病和骨髓增生异常综合征（MDS）患者的血管分布和血管生成因子的水平，测量了145例骨髓活检中的血管数量以及血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（bFGF）、肿瘤坏死生长因子-α的水平。 在 417 份血浆样本中测定了 (TNF-α)、肿瘤生长因子-α (TGF-α) 和肝细胞生长因子 (HGF)。除慢性淋巴细胞白血病（CLL）外，所有白血病和 MDS 的血管分布均显着高于对照骨髓。慢性粒细胞白血病 (CML) 的血管数量最多，血管面积最大；急性粒细胞白血病 (AML)、CML、CLL、慢性粒单核细胞白血病 (CMML) 和 MDS、HGF、TNF-α 和 bFGF 血浆中 VEGF、bFGF 和 HGF 水平显着升高，但不显着升高。 VEGF在急性淋巴细胞白血病（ALL）中显着升高，TNF-α水平在除AML和MDS之外的所有疾病中均显着升高，TGF-α在任何白血病或MDS中均未发现显着升高。 VEGF 的血浆水平最高的是 CML，bFGF 的血浆水平最高的是 CLL。 CMML 中 HGF 水平最高。这些数据表明，白血病和MDS中血管分布和血管生成因子增加，并且可能在白血病发生过程中发挥作用。 （血液，2000 年；96：2240-2245）（C）2000 年，美国血液学会。
Angiogenesis has been associated with the growth, dissemination, and metastasis of solid tumors. The aims of this study were to evaluate the vascularity and the levels of angiogenic factors in patients with acute and chronic leukemias and myelodysplastic syndromes (MDS), The numbers of blood vessels were measured in 145 bone marrow biopsies and the levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), tumor necrosis growth factor-alpha (TNF-alpha), tumor growth factor-alpha (TGF-alpha), and hepatocyte growth factor (HGF) were determined in 417 plasma samples. Except for chronic lymphocytic leukemia (CLL), vascularity was significantly higher in all leukemias and MDS compared with control bone marrows. The highest number of blood vessels and largest vascular area were found in chronic myeloid leukemia (CML), VEGF, bFGF, and HGF plasma levels were significantly increased in acute myeloid leukemia (AML), CML, CLL, chronic myelomonocytic leukemia (CMML), and MDS, HGF, TNF-alpha, and bFGF but not VEGF were significantly increased in acute lymphoblastic leukemia (ALL), TNF-alpha levels were significantly increased in all diseases except for AML and MDS, No significant increase was found in TGF-alpha in any leukemia or MDS. The highest plasma levels of VEGF were in CML, and the highest plasma levels of bFGF were in CLL. The levels of HGF were highest in CMML. These data suggest that vascularity and angiogenic factors are increased in leukemias and MDS and may play a role in the leukemogenic process. (Blood, 2000;96:2240-2245) (C) 2000 by The American Society of Hematology.