Modulation of sympathetic and somatomotor function by the ventromedial medulla.
Modulation of sympathetic and somatomotor function by the ventromedial medulla.
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腹内侧延髓调节交感神经和躯体运动功能。
DOI：
10.1152/jn.00089.2004
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Mason,Peggy
中科院分区：
文献类型：
--
作者：
NasonJr,MalcolmW;Mason,Peggy
延髓腹内侧区参与多种功能，包括伤害性和心血管调节以及体温调节的控制。将GABA受体拮抗剂荷包牡丹碱(70 nL，5-50 ng)注入轻度麻醉大鼠的延髓腹内侧部，记录心血管、呼吸和伤害性反应，以确定延髓腹内侧区单次注射GABA受体拮抗剂荷包牡丹碱是否引起一个或多个功能系统的改变。中缝中线或外侧邻近网状核内微量注射荷包牡丹碱，可同时增加肩峰间棕色脂肪组织温度、心率、血压、呼气二氧化碳浓度和呼吸频率，并引起寒战。荷包牡丹碱微量注射还可减少伤害性刺激引起的心率和血压变化，减少热刺激引起的叹息频率，抑制伤害性刺激引起的大脑皮层去同步化。虽然荷包牡丹碱抑制了由伤害性尾热引起的运动撤退，但它增强了由伤害性脚掌热引起的运动撤退，这是特定模式的伤害性调制的证据。中线或侧位微量注射生理盐水对任何测量变量均无影响。所有的荷包牡丹碱微量注射，无论是中线还是侧线，都引起了相同的一系列生理效应，与延髓腹内侧区缺乏局部组织的情况一致。此外，正如延髓腹内侧区细胞的等树突形态所预测的那样，中线荷包牡丹碱微量注射增加了中缝中线和外侧网状核中c-fos免疫反应细胞的数量。综上所述，延髓腹内侧区微量注射70-NL可激活多个核团中的细胞，并引起交感神经和躯体运动张力的增加，以及一种新的伤害性调制模式。
The ventromedial medulla is implicated in a variety of functions including nociceptive and cardiovascular modulation and the control of thermoregulation. To determine whether single microinjections into the ventromedial medulla elicit changes in one or multiple functional systems, the GABAAreceptor antagonist bicuculline was microinjected (70 nl, 5–50 ng) into the ventromedial medulla of lightly anesthetized rats, and cardiovascular, respiratory, and nociceptive measures were recorded. Bicuculline microinjection into either the midline raphe or the laterally adjacent reticular nucleus simultaneously increased interscapular brown adipose tissue temperature, heart rate, blood pressure, expired [CO2], and respiration rate and elicited shivering. Bicuculline microinjection also decreased the noxious stimulus-evoked changes in heart rate and blood pressure, decreased the frequency of heat-evoked sighs, and suppressed the cortical desynchronization evoked by noxious stimulation. Although bicuculline suppressed the motor withdrawal evoked by noxious tail heat, it enhanced the motor withdrawal evoked by noxious paw heat, evidence for specifically patterned nociceptive modulation. Saline microinjections into midline or lateral sites had no effect on any measured variable. All bicuculline microinjections, midline or lateral, evoked the same set of physiological effects, consistent with the lack of a topographical organization within the ventromedial medulla. Furthermore, as predicted by the isodendritic morphology of cells in the ventromedial medulla, midline bicuculline microinjection increased the number of c-fos immunoreactive cells in both midline raphe and lateral reticular nuclei. In summary, 70-nl microinjections into ventromedial medulla activate cells in multiple nuclei and elicit increases in sympathetic and somatomotor tone and a novel pattern of nociceptive modulation.