Efficient synthesis of cyclic imides by the tandem N-arylation-acylation and rearrangement reaction of cyanoesters with diaryliodonium salts
Efficient synthesis of cyclic imides by the tandem N-arylation-acylation and rearrangement reaction of cyanoesters with diaryliodonium salts
复制标题
通过氰基酯与二芳基碘鎓盐的串联N-芳基化-酰化和重排反应高效合成环状酰亚胺
DOI：
10.1016/j.cclet.2022.107913
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发表时间：
2023-03-16
影响因子：
9.1
通讯作者：
Chen, Chao
中科院分区：
文献类型：
--
作者：
Bao, Zhiyuan;Chen, Chao
开发了一种用氰基酯和二芳基碘鎓盐合成多取代环状酰亚胺的有效方法。该方法通过N-芳基化-酰化和重排的级联反应，以良好的产率（高达99%）得到目标杂环。该方法具有底物范围广、官能团相容性好等优点。该策略也被扩展到稠环酰亚胺，如丙二酰亚胺，琥珀酰亚胺和戊二酰亚胺。(c)2023由Elsevier B. V.代表中国化学会和中国医学科学院药物研究所出版。
Available online An efficient method for the synthesis of multi-substituted cyclic imides was developed with cyanoesters and diaryliodonium salts. This method proceeds through a cascade of N-arylation-acylation and rearrangement to give target heterocycles in good yields (up to 99%). This method has the major advantages of a broad substrate scope, excellent functional group compatibility. The strategy was also extended to the fused cyclic imides, such as malonimides, succinimides and glutarimides.(c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of MateriaMedica, Chinese Academy of Medical Sciences.