NAFLD, Estrogens, and Physical Exercise: The Animal Model.
NAFLD, Estrogens, and Physical Exercise: The Animal Model.
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DOI：
10.1155/2012/914938
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发表时间：
2012
影响因子：
2.2
通讯作者：
Pighon A
中科院分区：
文献类型：
--
作者：
Lavoie JM;Pighon A
绝经后女性是人群中特别倾向于肝脏脂肪堆积的一部分。尽管非酒精性肝脏脂肪变性在男性中比在女性中更常见，但绝经后性别分布发生了逆转。目前，减肥和运动被认为是绝经后妇女NAFLD的一线治疗方法，就像处理代谢综合征一样。近年来，有大量证据主要来自动物模型的使用，即雌激素的退出确实与有利于代谢途径活动的分子标志物的修饰有关，最终导致肝脏脂肪堆积。此外，动物模型的使用提供了生理和分子证据，表明运动训练对肝脏脂肪积累及其后果具有雌激素样的保护作用。本文的目的是介绍由于缺乏雌激素而导致的NAFLD状态的发展以及运动训练的作用，强调动物模型在这些问题上的贡献。
One segment of the population that is particularly inclined to liver fat accumulation is postmenopausal women. Although nonalcoholic hepatic steatosis is more common in men than in women, after menopause there is a reversal in gender distribution. At the present time, weight loss and exercise are regarded as first line treatments for NAFLD in postmenopausal women, as it is the case for the management of metabolic syndrome. In recent years, there has been substantial evidence coming mostly from the use of the animal model, that indeed estrogens withdrawal is associated with modifications of molecular markers favouring the activity of metabolic pathways ultimately leading to liver fat accumulation. In addition, the use of the animal model has provided physiological and molecular evidence that exercise training provides estrogens-like protective effects on liver fat accumulation and its consequences. The purpose of the present paper is to present information relative to the development of a state of NAFLD resulting from the absence of estrogens and the role of exercise training, emphasizing on the contribution of the animal model on these issues.