Immunologic regulation in pregnancy: from mechanism to therapeutic strategy for immunomodulation.
Immunologic regulation in pregnancy: from mechanism to therapeutic strategy for immunomodulation.
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DOI：
10.1155/2012/258391
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发表时间：
2012
影响因子：
--
通讯作者：
Sytwu HK
中科院分区：
文献类型：
--
作者：
Chen SJ;Liu YL;Sytwu HK
胎儿和母亲之间的免疫相互作用是一种矛盾的通信，其由胎儿抗原呈递和/或由母体免疫系统对这些抗原的识别和反应来调节。对胎盘床中母胎免疫关系异常的理解已经有了显著的进展，这些异常可能导致妊娠障碍。此外，妊娠的免疫识别对于妊娠的维持至关重要，并且对胎儿抗原的识别不足可能导致流产。在本文中，我们从人类白细胞抗原（HLA）、免疫细胞、细胞因子和趋化因子的作用以及怀孕期间免疫平衡等方面阐述了人类生殖的复杂免疫学方面。此外，我们还综述了人类生殖的免疫过程和目前妊娠病理性疾病的免疫治疗策略。
The immunologic interaction between the fetus and the mother is a paradoxical communication that is regulated by fetal antigen presentation and/or by recognition of and reaction to these antigens by the maternal immune system. There have been significant advances in understanding of abnormalities in the maternal-fetal immunologic relationship in the placental bed that can lead to pregnancy disorders. Moreover, immunologic recognition of pregnancy is vital for the maintenance of gestation, and inadequate recognition of fetal antigens may cause abortion. In this paper, we illustrate the complex immunologic aspects of human reproduction in terms of the role of human leukocyte antigen (HLA), immune cells, cytokines and chemokines, and the balance of immunity in pregnancy. In addition, we review the immunologic processes of human reproduction and the current immunologic therapeutic strategies for pathological disorders of pregnancy.