Regulation of Atherosclerosis Development by Neurotensin Derived From Lymphatic Endothelial Cells in Mice.
Regulation of Atherosclerosis Development by Neurotensin Derived From Lymphatic Endothelial Cells in Mice.
复制标题
DOI：
10.1161/atvbaha.123.319527
复制
发表时间：
2023-09
影响因子：
8.7
通讯作者：
Li, Jin
中科院分区：
文献类型：
--
作者：
Liu, Cenxi;Xiong, Xuelian;Li, Jin
NTS（神经降压素）是一种13个氨基酸的肽，与NTSR 1（神经降压素受体）、NTSR 2或SORT 1（分拣蛋白）蛋白相互作用。研究表明NTS与心血管疾病的发生呈正相关。1，2然而，由于NTS通过调节中枢神经系统对体温和食物摄入产生不同的影响，因此小鼠中NTS的组成性消耗不适合研究该主题。支持本研究结果的数据可根据合理要求从相应作者处获得。淋巴系统是循环系统的一部分，负责运输免疫细胞和脂质。淋巴管内皮细胞（LEC）也分泌各种蛋白质，如REELIN，这可能是重要的心血管系统。3了解这些分泌蛋白的生理功能是血管生物学的研究热点。我们以前的研究表明，LEC分泌NTS在各种组织，包括脂肪组织，皮肤和肝脏。4，5为了研究LEC衍生的NTS对动脉粥样硬化发展的影响，我们建立了一种可诱导的Nts敲除小鼠模型（C57 BL 6/J），
NTS (neurotensin) is a 13-amino acid peptide that interacts with NTSR1 (neurotensin receptor), NTSR2, or SORT1 (sortilin) proteins. Studies have shown positive correlations between NTS and the development of cardiovascular diseases. 1, 2 However, constitutive depletion of Nts in the mice is not suitable for investigating this topic, given the diverse effects of NTS on body temperature and food intake by regulating the central nervous system. The data that support the findings of this study are available from the corresponding author upon reasonable request.The lymphatic system, a part of the circulation system, transports the immune cells and lipids. Lymphatic endothelial cells (LECs) also secrete various proteins, such as REELIN, which may be important for the cardiovascular system. 3 Understanding the physiological functions of these secretory proteins is a research highlight in vascular biology. Our previous studies have shown that LECs secrete NTS in various tissues, including adipose tissues, skin, and liver. 4, 5 To investigate the effects of LEC-derived NTS on atherosclerosis development, we developed an inducible Nts knockout mouse model (C57BL6/J) restricted