Preventive Effects of Taurine on Development of Hepatic Steatosis Induced by a High-Fat/Cholesterol Dietary Habit
Preventive Effects of Taurine on Development of Hepatic Steatosis Induced by a High-Fat/Cholesterol Dietary Habit
复制标题
DOI：
10.1021/jf103167u
复制
发表时间：
2011-01-12
影响因子：
6.1
通讯作者：
Chen, Yi-Chen
中科院分区：
文献类型：
--
作者：
Chang, Yuan-Yen;Chou, Chung-Hsi;Chen, Yi-Chen
非酒精性脂肪肝（NAFL）也称为肝脂肪变性，已成为发达国家和发展中国家的一种紧急肝脏疾病。本研究旨在通过金黄地鼠脂肪肝动物模型，探讨牛磺酸（Tau）对脂肪肝的预防作用。尽管仓鼠的肝脂肪变性是通过喂食高脂肪/胆固醇饮食诱导的，但饮用含有0.35和0.7% Tau的水改善了（p < 0.05）血脂谱。同时，在高脂肪/胆固醇饮食的仓鼠中，饮用Tau的较小（p <0.05）肝脏尺寸和较低（p < 0.05）肝脏脂质可能部分归因于较高（p < 0.05）粪便胆固醇、三酰甘油和胆汁酸排出。在调节脂质稳态方面，饮用Tau溶液上调（p < 0.05）高脂肪/胆固醇饮食仓鼠的低密度脂蛋白受体和CYP 7A 1基因表达，从而导致粪便胆固醇和胆汁酸产量增加。饮用Tau溶液还上调（p < 0.05）高脂肪/胆固醇饮食仓鼠中的过氧化物酶体增殖物激活受体-a（PPAR-a）和解偶联蛋白2（UPC 2）基因表达，从而增加能量消耗。此外，Tau还能增强（p < 0.05）肝脏抗氧化能力（GSH、TEAC、SOD和CAT），降低（p < 0.05）脂质过氧化（MDA），从而减轻高脂/高胆固醇饮食仓鼠的肝脏损伤。因此，Tau对由高脂肪/胆固醇饮食习惯诱导的肝脂肪变性的发展显示出预防作用。
Nonalcoholic fatty liver (NAFL) is also called hepatic steatosis and has become an emergent liver disease in developed and developing nations. This study was to exam the preventive effects of taurine (Tau) on the development of hepatic steatosis via a hamster model. Although hepatic steatosis of hamsters was induced by feeding a high-fat/cholesterol diet, drinking water containing 0.35 and 0.7% Tau improved (p < 0.05) the serum lipid profile. Meanwhile, the smaller (p < 0.05) liver sizes and lower (p < 0.05) hepatic lipids in high-fat/cholesterol dietary hamsters drinking Tau may be partially due to higher (p < 0.05) fecal cholesterol, triacylglycerol, and bile acid outputs. In the regulation of lipid homeostasis, drinking a Tau solution upregulated (p < 0.05) low-density lipoprotein receptor and CYP7A1 gene expressions in high-fat/cholesterol dietary hamsters, which result in increased fecal cholesterol and bile acid outputs. Drinking a Tau solution also upregulated (p < 0.05) peroxisome proliferator-activated receptor-a (PPAR-a) and uncoupling protein 2 (UPC2) gene expressions in high-fat/cholesterol dietary hamsters, thus increasing energy expenditure. Besides, Tau also enhanced (p < 0.05) liver antioxidant capacities (GSH, TEAC, SOD, and CAT) and decreased (p < 0.05) lipid peroxidation (MDA), which alleviated liver damage in the high-fat/cholesterol dietary hamsters. Therefore, Tau shows preventive effects on the development of hepatic steatosis induced by a high-fat/cholesterol dietary habit.