Follicle stimulating hormone secreting pituitary microadenoma with fluctuating levels of ovarian hyperstimulation
Follicle stimulating hormone secreting pituitary microadenoma with fluctuating levels of ovarian hyperstimulation
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DOI：
10.1097/01.aog.0000141554.50747.16
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发表时间：
2005-05-01
影响因子：
7.2
通讯作者：
Yoshimura, Y
中科院分区：
文献类型：
--
作者：
Maruyama, T;Masuda, H;Yoshimura, Y
背景：据报道，育龄妇女的多囊卵巢增大和雌二醇（E2）浓度升高是促卵泡激素（FSH）分泌腺瘤的特征。然而，该激素与微腺瘤和卵巢发现相关的自然过程在很大程度上仍然未知。 病例：一名 40 岁多囊卵巢增大的女性经非手术诊断患有产生 FSH 的垂体微腺瘤。在随后 12 个月的随访中，血清 E2 浓度（而非 FSH）浓度出现显着波动，并且多囊卵巢的大小发生了剧烈波动。 E2水平和卵巢大小都暂时正常化。结论：由于疾病相关的波动，患有产生FSH的腺瘤的育龄妇女并不总是呈现卵巢过度刺激的实验室值特征。这一发现指出了诊断和临床管理中可能存在的缺陷。 (c) 2005 年，美国妇产科医师学会。
BACKGROUND: Enlarged multicystic ovaries and an elevated estradiol (E2) concentration have been reported as characteristics of follicle stimulating hormone (FSH)-secreting adenomas in reproductive-aged women. The natural course of the hormone in relationship to the microadenoma and ovarian findings, however, remains largely unknown.CASE: A 40-year-old woman with enlarged multicystic ovaries was nonsurgically diagnosed with an FSH-producing pituitary microadenoma. During her subsequent 12-month follow-up, the serum concentration of E2, but not FSH, and the size of the multicystic ovaries fluctuated dramatically. Both the E2 level and ovarian size were transiently normalized.CONCLUSION: Because of disease-related fluctuations, a reproductive-aged woman with an FSH-producing adenoma did not always present with laboratory values characteristic of ovarian hyperstimulation. This finding points out a possible pitfall in diagnosis and clinical management. (c) 2005 by The American College of Obstetricians and Gynecologists.