Assessment of the end-systolic pressure-volume relationship in human beings with the use of a time-varying elastance model.
Assessment of the end-systolic pressure-volume relationship in human beings with the use of a time-varying elastance model.
复制标题
使用时变弹性模型评估人类收缩末期压力-容积关系。
DOI：
10.1161/01.cir.74.1.97
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发表时间：
1986
期刊：
影响因子：
37.8
通讯作者：
W. Grossman
中科院分区：
文献类型：
--
作者：
R. McKay;J. Aroesty;G. Heller;H. Royal;S. Warren;W. Grossman
人类左心室收缩期末期压力-容积关系的分析一直受到一系列容积评估方法的缺乏和收缩期末期定义不精确的阻碍。为了避免这些问题，对收缩期末期关系的修改包括使用单点收缩期末期压力-容积比，使用峰值收缩期压力/最小心室容积点作为收缩期末期点，以及使用终射血作为收缩期末期的标志。为了评估这些修改产生的参数与Sagawa时变弹性模型定义的收缩末期线斜率（Emax）和体积截距（VO）之间的相关性，我们同时测量了26例患者在不同负荷条件下的左室压力和门控核素体积，并根据32个同时压力-体积坐标构建了每种负荷条件下的压力-体积图。14例患者记录2张压力-容积图，12例患者记录3张压力-容积图。所有患者的Emax和VO由Sagawa模型描述的具有最大时变弹性的等时压力-体积线的斜率和体积截距确定，分别为真Emax和真VO。（摘要删节250字）
The analysis of left ventricular end-systolic pressure-volume relationships in human beings has been hindered by the lack of a practical method of serial volume assessment and by an imprecise definition of end-systole. Modifications of the end-systolic relationship that have been used to circumvent these problems have included the use of single-point end-systolic pressure-volume ratios, the use of peak systolic pressure/minimum ventricular volume points for end-systolic points, and the use of end-ejection as a marker for end-systole. To assess the correlation between the parameters generated by these modifications with the slope (Emax) and volume intercept (VO) of the end-systolic line as defined by Sagawa's model of time-varying elastance, simultaneous measurement of left ventricular pressure and gated radionuclide volume was made in 26 patients under various loading conditions and pressure-volume diagrams were constructed for each loading condition from 32 simultaneous pressure-volume coordinates. Two pressure-volume diagrams were recorded in 14 patients and three pressure-volume diagrams were recorded in 12 patients. Emax and VO were determined in all patients from the slope and volume intercept of the isochronic pressure-volume line with the maximum time-varying elastance as described by Sagawa's model and were designated true Emax and true VO, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)