MBOAT7 rs641738 Variant Is Not Associated with an Increased Risk of Hepatocellular Carcinoma in a Latin American Cohort.
MBOAT7 rs641738 Variant Is Not Associated with an Increased Risk of Hepatocellular Carcinoma in a Latin American Cohort.
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MBOAT7 RS641738变体与拉丁美洲队列中肝细胞癌的风险增加无关。
DOI：
10.1007/s10620-023-08104-y
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发表时间：
2023-11
影响因子：
3.1
通讯作者：
Debes, Jose D.
中科院分区：
文献类型：
--
作者：
Goble, Spencer;Akambase, Joseph;Prieto, Jhon;Balderramo, Domingo;Ferrer, Javier Diaz;Mattos, Angelo Z.;Arrese, Marco;Carrera, Enrique;Groothuismink, Zwier M. A.;Oliveira, Jeffrey;Boonstra, Andre;Debes, Jose D.
MBOAT7的rs641738 C > T单核苷酸多态性与肝细胞癌（HCC）和非酒精性脂肪性肝病（NAFLD）相关。拉丁美洲的HCC和NAFLD发生率很高，但在该人群中尚未进行MBOAT7和HCC之间的评估。我们首次评估了MBOAT7对拉丁美洲人HCC风险的影响。患者被前瞻性地招募到ESCALON网络，旨在从6个南美国家（阿根廷、厄瓜多尔、巴西、智利、秘鲁和哥伦比亚）的拉丁美洲HCC患者中收集样本。纳入gnomAD数据库的欧洲队列和一般西班牙裔人群进行比较。使用逻辑回归评估HCC与MBOAT7之间的关系。总共评估了310例HCC和493例无HCC的肝硬化。MBOAT7 TT基因型不能预测拉丁美洲（TT vs CC OR调整= 1.15,95% CI 0.66-2.01, p = 0.610）或欧洲（TT vs CC OR调整= 1.20,95% CI 0.59-2.43, p = 0.621）的HCC。在NAFLD、病毒性肝炎或酒精相关性肝病的亚组分析中没有发现显著的相关性。与非肝硬化NAFLD队列相比，拉丁美洲NAFLD-肝硬化队列的TT基因型增加（TT vs CC + CT OR = 2.75, 95% CI 1.10-6.87, p = 0.031）。在拉丁美洲和欧洲，MBOAT7的rs631738 C > T等位基因与HCC风险增加无关。在拉丁美洲NAFLD患者中，TT基因型增加了肝硬化的风险。
The rs641738 C > T single-nucleotide polymorphism of MBOAT7 has been associated with hepatocellular carcinoma (HCC) and nonalcoholic fatty liver disease (NAFLD). Latin Americans have high rates of HCC and NAFLD, but no assessment between MBOAT7 and HCC has been performed in this population. We provide the first assessment of the impact of MBOAT7 on HCC risk in Latin Americans. Patients were prospectively recruited into the ESCALON network, designed to collect samples from Latin American patients with HCC in 6 South American countries (Argentina, Ecuador, Brazil, Chile, Peru, and Colombia). A European cohort and the general Hispanic population of gnomAD database were included for comparison. Associations between HCC and MBOAT7 were evaluated using logistic regression. In total, 310 cases of HCC and 493 cases of cirrhosis without HCC were assessed. The MBOAT7 TT genotype was not predictive of HCC in Latin Americans (TT vs CC OR adjusted = 1.15, 95% CI 0.66–2.01, p = 0.610) or Europeans (TT vs CC OR adjusted = 1.20, 95% CI 0.59–2.43, p = 0.621). No significant association was noted on subgroup analysis for NAFLD, viral hepatitis, or alcohol-related liver disease. The TT genotype was increased in the NAFLD-cirrhosis cohort of Latin Americans compared to a non-cirrhotic NAFLD cohort (TT vs CC + CT OR = 2.75, 95% CI 1.10–6.87, p = 0.031). The rs631738 C > T allele of MBOAT7 was not associated with increased risk of HCC in Latin Americans or Europeans. An increase in the risk of cirrhosis was noted with the TT genotype in Latin Americans with NAFLD.
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影响因子：
16.6
作者：
Alharthi, Jawaher;Bayoumi, Ali;Thabet, Khaled;Pan, Ziyan;Gloss, Brian S.;Latchoumanin, Olivier;Lundberg, Mischa;Twine, Natalie A.;McLeod, Duncan;Alenizi, Shafi;Adams, Leon A.;Weltman, Martin;Berg, Thomas;Liddle, Christopher;George, Jacob;Eslam, Mohammed
通讯作者：
Eslam, Mohammed
影响因子：
4.6
作者：
Donati B;Dongiovanni P;Romeo S;Meroni M;McCain M;Miele L;Petta S;Maier S;Rosso C;De Luca L;Vanni E;Grimaudo S;Romagnoli R;Colli F;Ferri F;Mancina RM;Iruzubieta P;Craxi A;Fracanzani AL;Grieco A;Corradini SG;Aghemo A;Colombo M;Soardo G;Bugianesi E;Reeves H;Anstee QM;Fargion S;Valenti L
通讯作者：
Valenti L
影响因子：
11.1
作者：
Dongiovanni P;Stender S;Pietrelli A;Mancina RM;Cespiati A;Petta S;Pelusi S;Pingitore P;Badiali S;Maggioni M;Mannisto V;Grimaudo S;Pipitone RM;Pihlajamaki J;Craxi A;Taube M;Carlsson LMS;Fargion S;Romeo S;Kozlitina J;Valenti L
通讯作者：
Valenti L
DOI：
10.1038/s41575-020-00381-6
发表时间：
2021-04
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
Huang DQ;El-Serag HB;Loomba R
通讯作者：
Loomba R
影响因子：
12.6
作者：
Koo, Bo Kyung;Joo, Sae Kyung;Kim, Won
通讯作者：
Kim, Won