Effects of a parenteral nutrition regimen containing dicarboxylic amino acids on plasma, erythrocyte, and urinary amino acid concentrations of young infants.
Effects of a parenteral nutrition regimen containing dicarboxylic amino acids on plasma, erythrocyte, and urinary amino acid concentrations of young infants.
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含有二羧酸氨基酸的肠外营养方案对小婴儿血浆、红细胞和尿氨基酸浓度的影响。
DOI：
10.1093/ajcn/37.1.99
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
L. Stegink
中科院分区：
文献类型：
--
作者：
E. Bell;L. Filer;A. Wong;L. Stegink
血浆，红细胞和尿中的氨基酸浓度进行了测量与含有谷氨酸盐和天冬氨酸溶液注入年幼的婴儿。8名婴儿（1.2 - 2.8 kg）在交叉设计中连续3天胃肠外（80 kcal/kg/天）喂食含葡萄糖（15 g/kg/天）、氨基酸（2 g/kg/天）和脂质（2 g/kg/天）的两种方案。两种方案仅在氨基酸来源上有所不同。一种方案（I）提供谷氨酸盐（1.5 mmol/kg/天）和天冬氨酸盐（1.0 mmol/kg/天），而另一种方案（II）不提供。在输注方案I期间，平均（+/- SD）血浆谷氨酸浓度略高于方案II（66.5 +/- 19.8 microM）（89.9 +/- 28.5 microM），但差异显著，但数值与正常口服喂养早产儿中观察到的数值（107 +/- 36 microM）无显著差异。血浆或红细胞天冬氨酸浓度或红细胞谷氨酸浓度均无显著差异。由于血浆和红细胞中的二羧酸氨基酸水平保持在正常范围内，因此数据表明输注该水平的二羧酸氨基酸对幼儿无危害。
Plasma, erythrocyte, and urinary amino acid concentrations were measured in young infants infused with a solution containing glutamate and aspartate. Eight infants (1.2 to 2.8 kg) were fed parenterally (80 kcal/kg/day) with two regimens containing dextrose (15 g/kg/day), amino acids (2 g/kg/day), and lipid (2 g/kg/day) for successive 3-day periods in a cross-over design. The regimens differed only in the amino acid source. One regimen (I) provided glutamate (1.5 mmol/kg/day) and aspartate (1.0 mmol/kg/day), while the other regimen (II) did not. The mean (+/- SD) plasma glutamate concentration was slightly, but significantly higher (89.9 +/- 28.5 microM) during infusion of regimen I than regimen II (66.5 +/- 19.8 microM), but values did not differ significantly from values observed in normal, orally fed premature infants (107 +/- 36 microM). No significant differences were noted in either plasma or erythrocyte aspartate concentrations, or in erythrocyte glutamate concentration. Since plasma and erythrocyte levels of dicarboxylic amino acids remained within the normal range, the data indicate no hazard to young infants from infusion of dicarboxylic amino acids at this level.