A study of heat shock protein 27 in endometrial carcinoma
A study of heat shock protein 27 in endometrial carcinoma
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DOI：
10.1006/gyno.1998.5283
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发表时间：
1999-03-01
影响因子：
4.7
通讯作者：
Zhou, Z
中科院分区：
文献类型：
--
作者：
Geisler, JP;Geisler, HE;Zhou, Z
目标。热休克蛋白27 （HSP27）是在病理生理应激反应中产生的一种相对较小的蛋白。本研究的目的是前瞻性地确定HSP27是否与子宫内膜癌患者已知的预后因素相关。本文对153例连续的子宫内膜癌患者进行了研究。用新鲜组织制备载玻片。采用半定量方法分析HSP27。检查患者记录FIGO分期、分级、肌层浸润深度、组织学、淋巴血管间隙浸润、复发时间和生存率。平均随访53个月（中位56个月，范围30-68个月）。子宫内膜样肿瘤的HSP27染色明显高于非子宫内膜样肿瘤（P = 0.005）。本研究结束时，存活患者的平均HSP27染色明显高于死亡患者（P < 0.001）， Logistic回归显示HSP27染色（P = 0.02）、FIGO分期（P = 0.014）和淋巴血管间隙浸润（P = 0.046）是预测存活的独立指标。子宫内膜样肿瘤的HSP27染色明显高于非子宫内膜样肿瘤。子宫内膜癌是美国最常见的妇科恶性肿瘤，HSP27染色是子宫内膜癌患者的独立预后指标。(C) 1999学术出版社。
Objective. Heat shock protein 27 (HSP27) is a relatively small protein produced in response to pathophysiologic stress. The purpose of this study was to determine prospectively whether HSP27 was associated with known prognostic factors in patients with endometrial carcinoma.Methods. One hundred fifty-three consecutive patients with endometrial carcinoma were studied. Slides were prepared from fresh tissue. HSP27 was analyzed using a semiquantitative measurement. Patient records were examined for FIGO stage, grade, depth of myometrial invasion, histology, lymphovascular space invasion, time to recurrence, and survival.Results. The mean follow-up was 53 months (median 56 months, range 30-68 months). Endometrioid tumors showed significantly higher HSP27 staining than nonendometrioid tumors (P = 0.005). Patients alive at the conclusion of this study had significantly higher mean HSP27 staining than patients who were deceased (P < 0.001), Logistic regression revealed HSP27 staining (P = 0.02), FIGO stage (P = 0.014), and lymphovascular space invasion (P = 0.046) to be independently predictive of survival.Conclusion. HSP27 staining is significantly higher in endometrioid than nonendometrioid tumors. HSP27 staining is an independent prognostic indicator in patients with endometrial carcinoma, the most common gynecologic malignancy in the United States. (C) 1999 Academic Press.