IMMUNE-REACTION AS A STIMULATOR OF TUMOR GROWTH
IMMUNE-REACTION AS A STIMULATOR OF TUMOR GROWTH
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DOI：
10.1126/science.176.4031.170
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发表时间：
1972-01-01
期刊：
影响因子：
56.9
通讯作者：
PREHN, RT
中科院分区：
文献类型：
--
作者：
PREHN, RT
将不同数量的特异性免疫小鼠脾脏细胞与一定数量的靶肿瘤细胞混合，并皮下接种到胸腺切除、x射线照射的受体中。与对照的非免疫脾细胞或免疫另一种非交叉反应肿瘤的动物脾细胞相比，少量混合免疫脾细胞在接种物中产生了统计学上显著的、可重复的肿瘤生长加速。然而，大量的特异性免疫脾细胞对肿瘤生长产生抑制作用。这些数据表明，正常的免疫反应可能具有与肿瘤有关的双重功能：(i)在病程早期或免疫反应最小时刺激肿瘤生长；（ii）在其他时间抑制肿瘤生长。
Various numbers of spleen cells from specifically immunized mice were mixed with constant numbers of target tumor cells, and were inoculated subcutaneously into thymectomized, x-irradiated recipients. Small numbers of admixed immune spleen cells produced a statistically significant, and reproducible, acceleration of tumor growth in the inoculum as compared with controls of either nonimmune spleen cells or spleen cells from animals immune to a different, noncross-reacting, tumor. Larger numbers of specifically immune spleen cells, however, produced inhibition of tumor growth. These data imply that the normal immune reaction may have a dual function in relation to neoplasia: (i) stimulation of tumor growth, early in the course of the disease, or whenever the immune reaction is minimal; (ii) inhibition of tumor growth at other times.