Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain.
Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain.
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成人的海马牙齿颗粒细胞正在进行成熟，调节大脑中的学习和记忆。
DOI：
10.1523/jneurosci.3362-09.2009
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发表时间：
2009-10-28
期刊：
影响因子：
--
通讯作者：
Gage FH
中科院分区：
文献类型：
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作者：
Deng W;Saxe MD;Gallina IS;Gage FH
成年出生的牙状颗粒细胞（DGCs）有助于学习和记忆，但它何时参与认知过程尚不清楚。在神经发生过程中，未成熟的齿状颗粒细胞（DGCs）在最终融入神经回路之前，在形态成熟过程中表现出独特的生理特征。在新生DGCs尚未成熟的关键时期，动物的经历会影响成年DGCs的存活和活性。为了评估成年神经发生的时间重要性，我们开发了一种转基因小鼠模型，使我们能够以一种暂时可调节的方式暂时减少成年出生的DGCs的数量。我们发现，在未成熟阶段，成年出生的DGCs数量减少的小鼠在形成强大的长期空间记忆方面存在缺陷，并且在灭绝任务中表现出受损的表现。这些结果表明，未成熟的DGCs经历成熟对学习和记忆有重要贡献。
Adult-born dentate granule cells (DGCs) contribute to learning and memory, yet it remains unknown when adult-born DGCs become involved in the cognitive processes. During neurogenesis, immature dentate granule cells (DGCs) display distinctive physiological characteristics while undergoing morphological maturation before final integration into the neural circuits. The survival and activity of the adult-born DGCs can be influenced by the experience of the animal during a critical period when newborn DGCs are still immature. To assess the temporal importance of adult neurogenesis, we developed a transgenic mouse model that allowed us to transiently reduce the numbers of adult-born DGCs in a temporally regulatable manner. We found that mice with a reduced population of adult-born DGCs at the immature stage were deficient in forming robust, long-term spatial memory and displayed impaired performance in extinction tasks. These results suggest that immature DGCs that undergo maturation make important contributions to learning and memory.