MAP-Kinase-Driven Hematopoietic Neoplasms: A Decade of Progress in the Molecular Age.
MAP-Kinase-Driven Hematopoietic Neoplasms: A Decade of Progress in the Molecular Age.
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DOI：
10.1101/cshperspect.a034892
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发表时间：
2021-05-03
影响因子：
5.4
通讯作者：
Durham BH
中科院分区：
文献类型：
--
作者：
Chakraborty R;Abdel-Wahab O;Durham BH
在上皮恶性肿瘤中广泛研究了丝裂原活化蛋白激酶（MAPK）通路成员的突变，BRAF突变是激活该通路的最常见改变之一。然而，BRAF突变在血液恶性肿瘤中总体上相当罕见。过去十年的研究已经确定了两组MAPK驱动的造血肿瘤中的高频BRAFV600 E、MAP2K1和其他激酶改变：毛细胞白血病（HCL）和系统性组织细胞病。尽管HCL和组织细胞病有共同的分子改变，但它们是表型不同的恶性肿瘤，在临床表现和可疑细胞来源方面有所不同。这篇综述的目的是强调在过去十年中的组织细胞肿瘤和HCL的分子进展，并讨论这些见解对我们理解这些神秘疾病的分子病理生理学，细胞起源和治疗的影响，以及未来的研究方向的前景。
Mutations in members of the mitogen-activated protein kinase (MAPK) pathway are extensively studied in epithelial malignancies, with BRAF mutations being one of the most common alterations activating this pathway. However, BRAF mutations are overall quite rare in hematological malignancies. Studies over the past decade have identified high-frequency BRAFV600E, MAP2K1, and other kinase alterations in two groups of MAPK-driven hematopoietic neoplasms: hairy cell leukemia (HCL) and the systemic histiocytoses. Despite HCL and histiocytoses sharing common molecular alterations, these are phenotypically distinct malignancies that differ in respect to clinical presentation and suspected cell of origin. The purpose of this review is to highlight the molecular advancements over the last decade in the histiocytic neoplasms and HCL and discuss the impact these insights have had on our understanding of the molecular pathophysiology, cellular origins, and therapy of these enigmatic diseases as well as perspectives for future research directions.
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DOI：
10.4049/jimmunol.0902336
发表时间：
2010-04-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Allen CE;Li L;Peters TL;Leung HC;Yu A;Man TK;Gurusiddappa S;Phillips MT;Hicks MJ;Gaikwad A;Merad M;McClain KL
通讯作者：
McClain KL
DOI：
10.1084/jem.20130977
发表时间：
2014-04-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Berres ML;Lim KP;Peters T;Price J;Takizawa H;Salmon H;Idoyaga J;Ruzo A;Lupo PJ;Hicks MJ;Shih A;Simko SJ;Abhyankar H;Chakraborty R;Leboeuf M;Beltrão M;Lira SA;Heym KM;Bigley V;Collin M;Manz MG;McClain K;Merad M;Allen CE
通讯作者：
Allen CE
影响因子：
20.3
作者：
Badalian-Very, Gayane;Vergilio, Jo-Anne;Rollins, Barrett J.
通讯作者：
Rollins, Barrett J.
DOI：
10.1182/asheducation-2015.1.559
发表时间：
2015-12-01
影响因子：
3
作者：
Allen, Carl E.;Parsons, D. Williams
通讯作者：
Parsons, D. Williams
影响因子：
20.3
作者：
Arons, Evgeny;Suntum, Tara;Kreitman, Robert J.
通讯作者：
Kreitman, Robert J.