MagScrew TAH: an update.
MagScrew TAH: an update.
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MagScrew TAH：更新。
DOI：
10.1097/01.mat.0000187395.29817.36
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Prisco
中科院分区：
文献类型：
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作者：
Weber,Stephan;Kamohara,Keiji;Klatte,RyanS;Luangphakdy,Viviane;Flick,Christine;Chen,Ji-Feng;Casas,Fernando;Ootaki,Yoshio;Kopcak,Michael;Akiyama,Masatoshi;Hirschman,GordonB;Chapman,PeterA;Donahue,Arthur;Wetterau,William;Prisco
目的：对被动填充、每搏量 45 毫升 MagScrew 全人工心脏 (TAH) 系统进行体外和体内测试。体外实验的重点是展示前负荷和后负荷敏感性、心房平衡和血流能力。体内研究的目标是证明所有植入系统组件的血液/生物相容性以及跑步机上的运动耐力。方法：体外研究利用模拟循环，在固定速率和自动控制模式下评估设备性能。体内实验是在小牛身上进行的。 TAH 系统在自动控制模式下运行。 结果：体外测试显示出出色的前负荷敏感性，在 220 BPM 的节拍速率、100 mm Hg 的全身平均后负荷和 13 mm Hg 的左心房压力下，装置流量高于 10 L/Min。在所有测试条件下均保持心房平衡。单独的测试表明后载灵敏度较低，设备流量高达 14 L/min，节拍速率高达 280 BPM。四项持续时间在 4-83 天之间的体内研究证实了体外结果，平均流量在 8.7-10.4 L/min 之间，平均节拍频率在 204-224 BPM 之间。在每次实验过程中，血流动力学保持正常，左右心房平衡良好。在任何动物中均未检测到溶血现象。终末器官功能维持良好，未发生血栓栓塞事件。所有动物运动耐量良好，无无氧代谢迹象。
Purpose:A passively filling, 45 ml stroke volume MagScrew Total Artificial Heart (TAH) system was tested in-vitro and in-vivo. Focus of the in-vitro experiments was the demonstration of preload and afterload sensitivity, atrial balance and flow capabilities. Goal of the in-vivo studies was the demonstration of blood/biocompatibility of all implanted system components and exercise tolerance on a treadmill.Methods:The in-vitro studies utilized a mock circulation, evaluating device performance in fixed rate and automatic control mode. The in-vivo experiments were conducted in calves. The TAH system was operated in automatic control mode.Results:In-vitro tests showed excellent preload sensitivity resulting in device flows above 10 L/Min at a beat rate of 220 BPM, at a systemic mean afterload of 100 mm Hg and a left atrial pressure of 13 mm Hg. Atrial balance was maintained at all tested conditions. Separate tests demonstrated low afterload sensitivity and a device flow of up to 14 L/min at beat rates of up to 280 BPM. Four in-vivo studies with durations between 4-83 days confirmed the in-vitro results with average flows ranging between 8.7–10.4 L/min at average beat rates ranging between 204–224 BPM. Hemodynamics remained normal with excellent left right atrial balance throughout the course of each experiment. Hemolysis was not detected in any animal. End-organ function was well maintained without thromoembolic events. The exercise tolerance of all animals was good, without signs of anaerobic metabolism.