Expression of estrogen receptors (α, β) and insulin-like growth factor-I in breast tissue from surgically postmenopausal cynomolgus macaques after long-term treatment with HRT and tamoxifen
Expression of estrogen receptors (α, β) and insulin-like growth factor-I in breast tissue from surgically postmenopausal cynomolgus macaques after long-term treatment with HRT and tamoxifen
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DOI：
10.1054/brst.2002.0422
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发表时间：
2002-08-01
期刊：
影响因子：
3.9
通讯作者：
Cline, JM
中科院分区：
文献类型：
--
作者：
Isaksson, E;Wang, H;Cline, JM
新的雌激素受体ER β可能是增殖和乳腺癌风险的关键因素。在长期HRT的灵长类动物模型中，手术绝经后食蟹猴用结合马雌激素（CEE）、醋酸甲羟孕酮（MPA）、CEE + MPA和他莫昔芬（所有组中n = 5）治疗35个月。免疫组织化学方法检测乳腺组织中ER α、ER β和IGF-I的表达。总体而言，ER β水平高于ER α。在未处理的动物中，阳性细胞的中位面积为58%和21%。在CEE/MPA治疗期间观察到ER β的最低水平（3%），并且在该组中ER β的表达低于ER α。他莫昔芬的作用类似于雌激素。ER β可能具有调节ER α激活后的增殖反应的作用。结果表明，激素治疗对乳腺组织中ER β/ER α的平衡有不同的影响。(C)2002爱思唯尔科技有限公司。保留所有权利。
The novel estrogen receptor ERbeta could be a key factor for proliferation and breast cancer risk. In a primate model for long-term HRT, surgically postmenopausal cynomolgus macaques were treated for 35 months with conjugated equine estrogens (CEE), medroxyprogesterone acetate (MPA), CEE + MPA and tamoxifen (n = 5 in all groups). The immunohistochemical expression of ERalpha, ERbeta and IGF-I in breast tissue was quantified by image analysis. Overall the levels of ERbeta were higher than for ERalpha. In untreated animals, the median area of positive cells was 58% and 21%. The lowest levels for ERbeta were seen during treatment with CEE/MPA (3%) and in this group the expression of ERbeta was lower than for ERalpha. Tamoxifen had effects similar to estrogen. ERbeta may have a role to modulate the proliferative response following activation of ERalpha. The results suggest that hormonal treatments have a different influence on the balance ERbeta/ERalpha in breast tissue. (C) 2002 Elsevier Science Ltd. All rights reserved.