Scallop genome provides insights into evolution of bilaterian karyotype and development
Scallop genome provides insights into evolution of bilaterian karyotype and development
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扇贝基因组为两侧对称动物核型的进化和发育提供了见解
DOI：
10.1038/s41559-017-0120
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发表时间：
2017-05-01
影响因子：
16.8
通讯作者：
Bao, Zhenmin
中科院分区：
文献类型：
--
作者：
Wang, Shi;Zhang, Jinbo;Bao, Zhenmin
重建两侧对称祖先的基因组是我们理解动物进化的核心，其中来自古老和/或缓慢进化的两侧对称谱系的知识至关重要。在这里，我们报告了一个高质量的，染色体锚定的参考基因组的扇贝Patinopecten yessoensis，一种双壳类软体动物，有一个缓慢进化的基因组与许多祖先的功能。基于染色体的宏同线性分析揭示了19条扇贝染色体与17个假定的祖先两侧对称连锁群之间的惊人对应，其保守程度达到了以前从未见过的水平，这表明扇贝的核型可能与两侧对称祖先的核型接近。扇贝Hox基因表达遵循一种新的模式，亚群时间共线性，这可能是祖先，并可能提供巨大的潜力，在支持不同的两侧对称的身体计划。扇贝外套膜眼睛的转录组分析发现了意想不到的多样性，在光转导级联和一个潜在的古老的Pax 2/5/8依赖途径的noncephalic眼睛。扇贝染色体组保存完好，是研究早期两侧对称动物进化和生物学的重要资源。
Reconstructing the genomes of bilaterian ancestors is central to our understanding of animal evolution, where knowledge from ancient and/or slow-evolving bilaterian lineages is critical. Here we report a high-quality, chromosome-anchored reference genome for the scallop Patinopecten yessoensis, a bivalve mollusc that has a slow-evolving genome with many ancestral features. Chromosome-based macrosynteny analysis reveals a striking correspondence between the 19 scallop chromosomes and the 17 presumed ancestral bilaterian linkage groups at a level of conservation previously unseen, suggesting that the scallop may have a karyotype close to that of the bilaterian ancestor. Scallop Hox gene expression follows a new mode of subcluster temporal co-linearity that is possibly ancestral and may provide great potential in supporting diverse bilaterian body plans. Transcriptome analysis of scallop mantle eyes finds unexpected diversity in phototransduction cascades and a potentially ancient Pax2/5/8-dependent pathway for noncephalic eyes. The outstanding preservation of ancestral karyotype and developmental control makes the scallop genome a valuable resource for understanding early bilaterian evolution and biology.