Factors related to sexual function in postmenopausal women with a history of breast cancer
Factors related to sexual function in postmenopausal women with a history of breast cancer
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DOI：
10.1097/00042192-200103000-00006
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发表时间：
2001-03-01
影响因子：
2.7
通讯作者：
Ganz, PA
中科院分区：
文献类型：
--
作者：
Greendale, GA;Petersen, L;Ganz, PA
背景：早期乳腺癌(BCS)幸存者的正常预期寿命强调了解决这些妇女长期生活质量问题的必要性。在乳腺癌治疗后，性功能障碍仍然存在，尽管在其他领域得到了恢复。目的：检验BCS的一系列特征与性别之间的关系。参与者：61名绝经后BCS的参与者，他们参加了一项针对更年期症状的非激素干预的随机对照试验，并有伴侣的亲密关系。方法：对基线试验数据进行横断面分析。结果是标准化的性趣、功能障碍和满意度量表。候选预测因素包括人口统计学、解剖学、医学、心理学、社会文化和荷尔蒙特征。结果：关系质量、阴道不适、教育程度和潮热分别与评估的三个性行为领域中的两个相关。其他10个因素进入预测模型：年龄、确诊时间、乳房保护、合并症、尿失禁、自认为健康、身体形象、生物可利用的睾丸素、黄体生成素和性激素结合球蛋白。这10个因素中的每一个都只与一个性取向领域相关。结论：在这一小样本的BCS中，我们发现了多个与性取向有关的因素。大多数似乎对性功能的个别领域产生了独特的影响。有几个特征是可以修改的，可能成为干预的目标。
Background: The normal life expectancy of survivors of early-stage breast cancer (BCS) underscores the need to address long-term quality of life issues in these women. Sexual dysfunction persists after breast cancer treatment, despite recovery in other domains.Objective: To examine associations between a broad array of characteristics and sexuality in BCS.Participants: Sixty-one postmenopausal BCS who were participants in a randomized, controlled trial of nonhormonal interventions for menopause symptoms and who had a partnered, intimate relationship.Methods: Cross-sectional analysis of baseline trial data. Outcomes were standardized scales of sexual interest, dysfunction, and satisfaction. Candidate predictors included demographic, anatomical, medical, psychological, sociocultural, and hormonal characteristics. Forward, stepwise regression was used.Results: Relationship quality, vaginal discomfort, education, and hot flashes were each associated with two of the three domains of sexuality assessed. Ten other factors entered predictive models: age, time since diagnosis, breast conservation, comorbidity, urinary incontinence, perceived health, body image, bioavailable testosterone, luteinizing hormone, and sex hormone binding globulin. Each of these 10 factors was associated with only one sexuality domain.Conclusions: In this small sample of BCS, we found multiple correlates of sexuality. Most seem to impact uniquely on individual domains of sexual function. Several characteristics are modifiable and could be targets for intervention.