Factors in allergen‐induced asthma: relevance of the intensity of the airways allergic reaction and non‐specific bronchial reactivity
Factors in allergen‐induced asthma: relevance of the intensity of the airways allergic reaction and non‐specific bronchial reactivity
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过敏原诱发哮喘的因素：气道过敏反应强度与非特异性支气管反应性的相关性
DOI：
10.1111/j.1365-2222.1976.tb01900.x
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发表时间：
1976
影响因子：
6.1
通讯作者：
J. Dolovich
中科院分区：
文献类型：
--
作者：
D. Killian;D. Cockcroft;F. Hargreave;J. Dolovich
在9例哮喘患者中，吸入过敏原引起的早期哮喘反应（EAR）的严重程度相似。呼吸道过敏反应的严重程度是通过测量由引起EAR的过敏原相同稀释度产生的皮肤试验伤口大小来估计的。非特异性支气管反应性通过吸入浓度增加的磷酸组胺来评估。研究了气道过敏反应的严重程度、非特异性支气管高反应性水平和哮喘反应模式之间可能存在的关系。
Early asthmatic responses (EAR) of similar severity were produced by allergen inhalation challenges in nine asthmatic subjects. The severity of the airways allergic reaction was estimated by measuring the skin test weal size produced by the same dilution of allergen which caused the EAR. The non‐specific bronchial reactivity was assessed by inhalation of increasing concentrations of histamine acid phosphate. Possible relationships between the severity of the airways allergic reaction, the level of non‐specific bronchial hyper‐reactivity and the pattern of asthmatic response were examined.