An overview of the biological significance of endogenous gases: new roles for old molecules
An overview of the biological significance of endogenous gases: new roles for old molecules
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DOI：
10.1042/bst0351138
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发表时间：
2007-11-01
影响因子：
3.9
通讯作者：
Moore, P. K.
中科院分区：
文献类型：
--
作者：
Li, L.;Moore, P. K.
体内自然产生的生物活性气体包括一氧化氮（NO）、一氧化碳（CO）和硫化氢（H2S）。这些分子中的每一种都是由已经被生物化学和生物学表征的酶合成的，并且每一种都通过良好建立的分子靶标作用以影响体内的生理和/或病理生理功能。所有三种气体共同的主要生物学作用包括调节血管稳态和中枢神经系统功能。越来越清楚的是，每种气体的合成和生物活性在某种程度上都受其他气体的存在的调节，因此，有必要考虑这些分子不是孤立的，而是一起作用以控制细胞功能。此外，气态细胞信号分子的更多推测候选者包括氨、乙醛、二氧化硫和一氧化二氮。这些分子是否也在调节身体功能中发挥作用仍有待确定。
Biologically active gases that occur naturally in the body include nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S). Each of these molecules is synthesized by enzymes which have been characterized biochemically and pharmacologically, and each acts, via well-established molecular targets, to effect physiological and/or pathophysiological functions within the body. Major biological roles that appear to be common to all three gases include the regulation of vascular homoeostasis and central nervous system function. it is becoming increasingly clear that both the synthesis and the biological activity of each gas are, to some extent, regulated by the presence of the others, and as such it is necessary to consider these molecules not in isolation but acting together to control cell function. Additional, more speculative candidates for gaseous cell signalling molecules include ammonia, acetaldehyde, sulfur dioxide and nitrous oxide. Whether such molecules also play a role in regulating body function remains to be determined.