Protection against photodynamic therapy (PDT)-induced photosensitivity by fabric materials.
Protection against photodynamic therapy (PDT)-induced photosensitivity by fabric materials.
复制标题
通过织物材料防止光动力疗法 (PDT) 引起的光敏性。
DOI：
10.1111/j.1600-0781.1998.tb00034.x
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Hughes,SN
中科院分区：
文献类型：
--
作者：
Menter,JM;Hollins,TD;Sayre,RM;Etemadi,AA;Willis,I;Hughes,SN
“特殊的”高防护织物现在可以提供广谱保护，防止晒伤，以及可能的其他类型的光损伤。了解这些织物在多大程度上能够保护穿戴者免受皮肤癌、光敏性疾病和光动力疗法（PDT）引起的无意的光毒性反应是很重要的。我们评估了一种这样的特殊（Solumbra）织物和一种“典型”夏季织物的能力，以防止局部5 -氨基乙酰丙酸（ALA）和（主要）可见光（360-800 nm）在胶带剥离的Sk‐1无毛小鼠中产生的PDT光毒性。由于ALA衍生的光敏剂吸收了大部分可见光谱，因此这些研究的结果很好地表明了这些织物在整个区域的光防护能力。用装有300 W钨卤灯（I0=48.3 mW/cm2）的柯达幻灯机对小鼠进行背侧照射。在确定最小光毒性剂量（MPD）为1.40±0.4 J/cm2后，我们通过拉伸的测试织物以适当倍数的MPD照射胶带剥离的ALA致敏小鼠。这种特殊织物对14/14只小鼠在360-800 nm范围内的25-30 MPD可见光具有保护作用。典型的织物不能提供2.5 MPD相同频谱的保护。ALA或光照控制均未见光毒性或其他不良反应。综上所述，Solumbra织物对ALA光敏的保护作用比典型织物强得多。两者都比可见光更能阻挡紫外线。
“Special” highly protective fabrics are now available that offer broad‐spectrum protection in preventing sunburn, and possibly other types of photodamage. It is important to know to what extent these fabrics are capable of protecting the wearer against skin cancer, photosensitivity disorders, and inadvertent phototoxic reactions from photodynamic therapy (PDT). We assess the ability of one such special (Solumbra) fabric and one “typical” summer fabric to provide protection against PDT phototoxicity produced in tape‐stripped Sk‐1 hairless mice by topical 5‐aminolevulinic acid (ALA) and (primarily) visible light (360–800 nm). Since ALA‐derived photosensitizers absorb most of the visible spectrum, results from these studies give a good indication of the photoprotective capability of these fabrics throughout this region. Mice were irradiated dorsally with a Kodak slide projector equipped with a 300 W tungsten‐halogen lamp (I0=48.3 mW/cm2). After determining the minimal phototoxic dose (MPD) to be 1.40±0.4 J/cm2, we irradiated the tape‐stripped ALA‐sensitized mice through the stretched test fabrics with appropriate multiples of the MPD. The special fabric provided protection against 25–30 MPD visible light between 360–800 nm in 14/14 mice. The typical fabric failed to provide protection against 2.5 MPD of the same spectrum. No phototoxic or other adverse responses were seen with either the ALA or light control. In conclusion, the Solumbra fabric is much more protective against ALA photosensitization than the typical fabric. Both appear better at blocking UV than visible light.