5-year follow-up study of children with low-to-moderate lead absorption: electrophysiological evaluation.
5-year follow-up study of children with low-to-moderate lead absorption: electrophysiological evaluation.
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低至中度铅吸收儿童的 5 年随访研究：电生理学评估。
DOI：
10.1016/0013-9351(85)90082-9
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发表时间：
1985
影响因子：
8.3
通讯作者：
L. Boone
中科院分区：
文献类型：
--
作者：
D. Otto;G. Robinson;S. Baumann;S. Schroeder;P. Mushak;D. Kleinbaum;L. Boone
49名6至12岁的儿童在最初评估5年后，通过心理测量、电生理和医学测试评估了铅暴露的残余影响。血铅的原始范围为6-59(x̄=28)μg/dl，当前范围为6-30(x̄=14)μg/dl。在最初的评估和2年的随访中，观察到感觉条件反射过程中PBB和慢脑波电压之间存在线性关系。在5年的随访期中，被动条件反射时的PBB与慢波电压之间没有明显的关系，尽管探索性分析表明，在主动条件反射期间，慢波负性相对于当前的PBB水平呈线性增加。另一项探索性分析显示，原始PBB水平与脑干听觉诱发电位的波III和V的潜伏期之间存在显著的线性关系。两波潜伏期均随初始PBB增加而延长。这些波的潜伏期延长提示耳蜗核吻侧听觉通路的亚临床病理，尽管不能排除终末器官损害的可能性。铅对听功能的影响无明显阈值。
Forty-nine children aged 6 to 12 years were evaluated for residual effects of lead exposure using psychometric, electrophysiological, and medical tests 5 years after initial assessment. The original range of blood lead (PbB) levels was 6–59 (x ̄= 28) μg/dl; the current range was 6–30 (x ̄= 14) μg/dl. A linear relationship between PbB and slow brain wave voltage during sensory conditioning was observed at initial evaluation and at 2-year follow-up. No significant relationship between PbB and slow wave voltage during passive conditioning was found at the 5-year follow-up, although a linear increase in slow wave negativity relative to the current PbB level during active conditioning was suggested by exploratory analyses. Another exploratory analysis revealed a significant linear relationship between the original PbB levels and the latency of waves III and V of the brainstem auditory evoked potential. The latency of both waves increased as a function of original PbB. Increased latency of these waves is suggestive of subclinical pathology of the auditory pathway rostral to the cochlear nucleus, although end-organ impairment cannot be ruled out. No threshold for the effect of Pb on auditory function was apparent.
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喜马拉雅偏远地区人群的血铅浓度。
DOI：
10.1126/science.7444442
发表时间：
1980
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Piomelli,S;Corash,L;Corash,MB;Seaman,C;Mushak,P;Glover,B;Padgett,R
通讯作者：
Padgett,R
低至中度铅暴露对幼儿慢皮质电位的影响：两年随访研究。
DOI：
--
发表时间：
1982
期刊：
Neurobehavioral toxicology and teratology
影响因子：
--
作者：
Otto,D;Benignus,V;Muller,K;Barton,C;Seiple,K;Prah,J;Schroeder,S
通讯作者：
Schroeder,S
DOI：
10.1016/0013-4694(81)90052-3
发表时间：
1981-10
期刊：
Electroencephalography and clinical neurophysiology
影响因子：
--
作者：
D. Otto;V. Benignus;V. Benignus;K. E. Muller;C. Barton
通讯作者：
D. Otto;V. Benignus;V. Benignus;K. E. Muller;C. Barton
区分铅和社会因素对智商的影响。
影响因子：
8.3
作者：
Schroeder,SR;Hawk,B;Otto,DA;Mushak,P;Hicks,RE
通讯作者：
Hicks,RE