Sex differences in attentional processes in adult rats as measured by performance on the 5-choice serial reaction time task
Sex differences in attentional processes in adult rats as measured by performance on the 5-choice serial reaction time task
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DOI：
10.1016/j.bbr.2012.07.028
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发表时间：
2012-11-01
影响因子：
2.7
通讯作者：
Daniel, Jill M.
中科院分区：
文献类型：
--
作者：
Bayless, Daniel W.;Darling, Jeff S.;Daniel, Jill M.
本研究的目的是探讨性别差异的注意过程中，成年大鼠使用的注意测试表明，是依赖于前额叶皮层。对雄性和雌性成年Long-Evans大鼠进行5选择系列反应时任务训练。这项任务要求大鼠在五个可能的位置中识别短暂的光刺激的位置。在基线条件下和行为挑战条件下评估性能，在此期间任务难度增加。行为挑战条件包括缩短刺激持续时间、缩短刺激开始前的时间、延长刺激开始前的时间以及呈现分散注意力的噪声。基线和所有激发条件下的分析显示，雌性大鼠的警惕性或持续注意力比雄性大鼠更容易受到干扰，如正确百分比和遗漏数量所示。分析还显示，抑制控制在雄性大鼠中比在雌性大鼠中更容易被破坏，如通过过早反应的数量所测量的。当刺激的开始时间不可预测地延长时，这些差异最为突出。奖励收集潜伏期或正确反应潜伏期没有差异，表明两性之间的动机或感觉过程没有差异。这些结果表明，在具有挑战性的条件下，成年雌性大鼠比成年雄性大鼠更容易犯错误的警觉，成年雄性大鼠比成年雌性大鼠更容易犯错误的抑制控制。(c)2012爱思唯尔有限公司版权所有。
The goal of the current study was to explore sex differences in attentional processes in adult rats using a test of attention shown to be dependent upon the prefrontal cortex. Male and female adult Long-Evans rats were trained on the 5-choice serial reaction time task. This task requires rats to identify the location of a brief light stimulus among five possible locations. Performance was assessed under baseline conditions and under behavioral challenge conditions during which task difficulty was increased. Behavioral challenge conditions included shortening the stimulus duration, shortening the time before the onset of the stimulus, lengthening the time before the onset of the stimulus, and presenting a distracting noise. Analyses across baseline and all challenge conditions revealed that vigilance or sustained attention was more disrupted in female rats than it was in male rats, as measured by percent correct and number of omissions. Analyses also revealed that inhibitory control was more disrupted in male rats than it was in female rats, as measured by number of premature responses. These differences were most prominent when the onset of the stimulus was unpredictably lengthened. There were no differences in reward collection latency or correct response latency indicating no differences in motivation or sensory processes between the sexes. These results indicate that under challenging conditions adult female rats are more prone to make errors of vigilance than are adult male rats, and adult male rats are more prone to make errors of inhibitory control than are adult female rats. (c) 2012 Elsevier B.V. All rights reserved.