Co-morbidities associated with influenza-attributed mortality, 1994-2000,Canada
Co-morbidities associated with influenza-attributed mortality, 1994-2000,Canada
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DOI：
10.1016/j.vaccine.2008.06.087
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发表时间：
2008-08-26
期刊：
影响因子：
5.5
通讯作者：
Tam, Theresa W. S.
中科院分区：
文献类型：
--
作者：
Schanzer, Dena L.;Langley, Joanne M.;Tam, Theresa W. S.
众所周知，老年人和患有特定慢性病的人因感染流感而面临更高的发病率和死亡风险，因此经常建议他们每年接种流感疫苗。然而，尚未确定特定风险的死亡率。我们根据我国数据库中记录的因呼吸道并发症入院的患者的死亡情况，根据慢性病的存在和居住类型，估计了特定年龄的流感可归因性死亡率。大多数患者有慢性心脏或呼吸系统疾病(80%)，并且是从社区住院(80%)。在所有风险群体中，流感可归因性死亡率随着年龄的增长而明显增加。与其他方法相比，特定于流感的CUR估计确定了更高的慢性肺病或心脏病风险比。这些估计确定了最需要改进疫苗的群体，对他们应该考虑使用额外的战略，如对家庭接触者或照顾者进行免疫接种。皇冠版权所有(C)2008由爱思唯尔有限公司出版。保留所有权利。
The elderly and persons with specific chronic conditions are known to face elevated Morbidity and mortality risks resulting from an influenza infection, and hence are routinely recommended for annual influenza vaccination. However, risk-specific mortality rates have not been established. We estimated age-specific influenza-attributable mortality rates stratified by the presence of chronic conditions and type of residence based on deaths of persons who were admitted to hospital with a respiratory complication captured in our national database. The majority of patients had chronic heart or respiratory conditions (80%) and were admitted from the community (80%). Influenza-attributable mortality rates clearly increase with age for all risk groups. Cur influenza-specific estimates identified higher risk ratios for chronic lung or heart disease than have been suggested by other methods. These estimates identify groups most in need of improved vaccines and for whom the use of additional strategies, such as immunization of household contacts or caregivers should be considered. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.