Impact of the ovulatory cycle on virologic and immunologic markers in HIV-infected women
Impact of the ovulatory cycle on virologic and immunologic markers in HIV-infected women
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DOI：
10.1086/315207
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发表时间：
2000-01-01
影响因子：
6.4
通讯作者：
Taylor, RN
中科院分区：
文献类型：
--
作者：
Greenblatt, RM;Ameli, N;Taylor, RN
个体的性别影响血浆人类免疫缺陷病毒1型(HIV-1)RNA水平和CD4细胞下降的速度，但这种影响的机制目前尚不清楚。为了确定排卵周期对HIV感染女性的HIV-1RNA水平和淋巴细胞亚群的影响，研究人员每周采集14名感染HIV的女性的血液样本，参与者报告有规律的月经，没有使用激素药物或麻醉剂。用内分泌指标证实排卵的发生。14名女性中有10名发生排卵。在排卵的妇女中，从早期卵泡期到黄体中期，HIV-1RNA水平的中位数下降了0.16log(10)(P=0.03，Wilcoxon符号等级检验)。当没有排卵的妇女被包括在分析中时，血浆HIV RNA水平没有明显的波动。因此，排卵周期影响循环中的HIV-1RNA水平，这一发现是可信的，因为已知性激素对淋巴细胞功能和细胞因子产生的影响。
An individual's sex influences plasma human immunodeficiency virus type 1 (HIV-1) RNA level and rate of CD4 cell decline, but the mechanism for this effect is currently unknown. To determine the effect of the ovulatory cycle on HIV-1 RNA level and lymphocyte subsets in HIV-infected women, blood specimens were obtained weekly from 14 women infected with HIV, Participants reported regular menses and were not using hormonal medications or narcotics. The occurrence of ovulation was verified by use of endocrine criteria. Ovulation occurred in 10 of the 14 women. Among women who ovulated, median HIV-1 RNA level fell by a median of 0.16 log(10) from the early follicular phase to the midluteal phase (P = .03, Wilcoxon signed-rank test). When women who did not ovulate were included in the analysis, no significant fluctuation in plasma HIV RNA level was identified. Thus, the ovulatory cycle influenced circulating HIV-1 RNA levels, a finding that is plausible because of the known effect of sex hormones on lymphocyte function and cytokine production.