Exposure-Specific and Age-Specific Attack Rates for Ebola Virus Disease in Ebola-Affected Households, Sierra Leone.
Exposure-Specific and Age-Specific Attack Rates for Ebola Virus Disease in Ebola-Affected Households, Sierra Leone.
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塞拉利昂受埃博拉病毒影响的家庭中特定暴露和特定年龄的埃博拉病毒病发病率。
DOI：
10.3201/eid2208.160163
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发表时间：
2016-08
影响因子：
11.8
通讯作者：
Glynn JR
中科院分区：
文献类型：
--
作者：
Bower H;Johnson S;Bangura MS;Kamara AJ;Kamara O;Mansaray SH;Sesay D;Turay C;Checchi F;Glynn JR
患病风险与接触程度相关，5-19岁儿童患病风险最低。使用塞拉利昂埃博拉病毒病（EVD）幸存者的家庭成员的历史，我们按年龄和暴露水平计算了EVD的风险，调整了混杂和聚类，并估计了相对风险。在94个家庭的937名家庭成员中，448名（48%）患有EVD。EVD风险与接触高度相关，从接触尸体的83%到最小接触的8%不等，并因年龄组而异：2岁以下儿童为43%; 5-14岁为30%; 30岁以上成人为60%。与20-29岁人群的风险相比，5-9岁（0.70）、10-14岁（0.64）和15-19岁（0.71）人群的暴露调整相对风险较低，但<2岁（0.92）或2-4岁（0.97）的儿童则不然。在调整暴露后，5-19岁的风险较低，表明该组的易感性降低。
Risk for disease correlated with level of exposure and was lowest for children 5–19 years of age. Using histories of household members of Ebola virus disease (EVD) survivors in Sierra Leone, we calculated risk of EVD by age and exposure level, adjusting for confounding and clustering, and estimated relative risks. Of 937 household members in 94 households, 448 (48%) had had EVD. Highly correlated with exposure, EVD risk ranged from 83% for touching a corpse to 8% for minimal contact and varied by age group: 43% for children <2 years of age; 30% for those 5–14 years of age; and >60% for adults >30 years of age. Compared with risk for persons 20–29 years of age, exposure-adjusted relative risks were lower for those 5–9 (0.70), 10–14 (0.64), and 15–19 (0.71) years of age but not for children <2 (0.92) or 2–4 (0.97) years of age. Lower risk for 5–19-year-olds, after adjustment for exposure, suggests decreased susceptibility in this group.