Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning
Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning
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DOI：
10.1371/journal.pone.0222064
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发表时间：
2019-09-19
期刊：
影响因子：
3.7
通讯作者：
Burman, Douglas D.
中科院分区：
文献类型：
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作者：
Burman, Douglas D.
海马体与运动系统的相互作用通常被认为反映了记忆在运动学习中的作用。在这里，我们检查了在两个需要有节奏的动作的任务中，海马体与感觉运动皮质的连通性，一个有助记成分(顺序学习)，另一个没有(重复敲击)。记录了13名右利手受试者的功能性磁共振成像活动；通过运动和被动视觉任务之间的海马区活动中感觉运动皮质与心理生理相互作用的相关性来确定连接性。在两项运动任务中，手指的运动都提前了节拍器的时间，反映了认知控制，然而运动学习的证据仅限于序列学习任务；尽管如此，在两项任务中都观察到了海马区的连接。来自左侧和右侧海马体相应区域的连接性广泛重叠，它们的联合(全局)分析提高了敏感度。正连接和负连接都是明显的，在单侧运动时，运动手同侧感觉运动皮质的正连接，而负连接在运动中最活跃的大脑半球显著。结果表明，即使在没有运动学习或回忆的情况下，海马体也参与了手指的任意性运动。
Hippocampal interactions with the motor system are often assumed to reflect the role of memory in motor learning. Here, we examine hippocampal connectivity with sensorimotor cortex during two tasks requiring paced movements, one with a mnemonic component (sequence learning) and one without (repetitive tapping). Functional magnetic resonance imaging activity was recorded from thirteen right-handed subjects; connectivity was identified from sensorimotor cortex correlations with psychophysiological interactions in hippocampal activity between motor and passive visual tasks. Finger movements in both motor tasks anticipated the timing of the metronome, reflecting cognitive control, yet evidence of motor learning was limited to the sequence learning task; nonetheless, hippocampal connectivity was observed during both tasks. Connectivity from corresponding regions in the left and right hippocampus overlapped extensively, with improved sensitivity resulting from their conjunctive (global) analysis. Positive and negative connectivity were both evident, with positive connectivity in sensorimotor cortex ipsilateral to the moving hand during unilateral movements, whereas negative connectivity was prominent in whichever hemisphere was most active during movements. Results implicate the hippocampus in volitional finger movements even in the absence of motor learning or recall.