Wiskott-Aldrich syndrome proteins in the nucleus: aWASH with possibilities.
Wiskott-Aldrich syndrome proteins in the nucleus: aWASH with possibilities.
复制标题
细胞核中的 Wiskott-Aldrich 综合征蛋白：aWASH 的可能性。
DOI：
10.1080/19491034.2015.1086051
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Parkhurst,SusanM
中科院分区：
文献类型：
--
作者：
Verboon,JeffreyM;Sugumar,Bina;Parkhurst,SusanM
Actin and proteins that regulate its dynamics or interactions have well-established roles in the cytoplasm where they function as key components of the cytoskeleton to control diverse processes, including cellular infrastructure, cellular motility, cell signaling, and vesicle transport. Recent work has also uncovered roles for actin and its regulatory proteins in the nucleus, primarily in mechanisms governing gene expression. The Wiskott Aldrich Syndrome (WAS) family of proteins, comprising the WASP/N-WASP, SCAR/WAVE, WHAMM/JMY/WHAMY, and WASH subfamilies, function in the cytoplasm where they activate the Arp2/3 complex to form branched actin filaments. WAS proteins are present in the nucleus and have been implicated as transcriptional regulators. We found that Drosophila Wash, in addition to transcriptional effects, is involved in global nuclear architecture. Here we summarize the regulation and function of nuclear WAS proteins, and highlight how our work with Wash expands the possibilities for the functions of these proteins in the nucleus.
