Microscopic polyangiitis associated with sinobronchial syndrome.
Microscopic polyangiitis associated with sinobronchial syndrome.
复制标题
与窦支气管综合征相关的显微镜下多血管炎。
作者：
Taiji Nagata;K. Hara;Teruaki Oka;Y. Yamauchi;K. Igarashi;H. Hazama;Masao Omata
一名长期患有慢性支气管炎和慢性鼻窦炎，即鼻窦-支气管炎综合征的妇女，因发烧入院。放射学上，双肺有长期实变的区域，镓-67核素扫描显示炎症活跃的区域。髓过氧化物酶特异性抗中性粒细胞胞浆抗体呈强阳性。入院2周后出现肺出血和血尿，激素治疗有效。然而，这名患者死于肺炎。尸检显示全身性坏死性脉管炎累及多个器官，与显微镜下的多血管炎一致。血管炎可能是由与窦-支综合征相关的肺部慢性炎症引起的。
A woman with a long history of chronic bronchitis and chronic sinusitis, i.e., sinobronchial syndrome, was admitted with a fever. Radiologically, there were areas of longstanding consolidation in both lungs, with areas of active inflammation demonstrated by gallium-67 scintigraphy. Antineutrophil cytoplasmic antibody specific for myeloperoxidase was highly positive. Pulmonary hemorrhage and hematuria occurred 2 weeks after admission and responded to steroid therapy. However, the patient died of pneumonia. An autopsy revealed systemic necrotizing vasculitis affecting multiple organs, consistent with microscopic polyangiitis. The vasculitis might have been caused by the chronic inflammation in the lungs associated with sinobronchial syndrome.