The site of cardiovascular action of angiotensin II in the brain.
The site of cardiovascular action of angiotensin II in the brain.
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血管紧张素 II 在大脑中的心血管作用部位。
DOI：
10.1042/cs0390327
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发表时间：
1970
期刊：
影响因子：
6
通讯作者：
R. Lowe
中科院分区：
文献类型：
--
作者：
M. Joy;R. Lowe
1.在氯醛糖麻醉的灰狗中研究了椎动脉灌注血管紧张素的作用部位。2.夹闭脑桥和锥体交叉之间的基底动脉并不能降低椎动脉灌注血管紧张素（0·25-2·0 ng kg −1 min −1）引起的心血管反应。血管紧张素通过导管以头侧方向插入钳夹上方的基底动脉，对血管紧张素输注无反应。因此，作用部位必须位于脑桥尾侧。3.在第一颈段脊髓横断并没有取消椎动脉灌注的反应，这仍然是由迷走神经介导的，并取消了随后的迷走神经切断术。因此，作用部位必须位于颈髓的嘴侧。4.局部注入血管紧张素到供应髓质的小动脉产生的反应类似于椎动脉血管紧张素灌注。5.这些结果表明，负责血管紧张素的这些中枢作用的网站位于髓质。
1. The site of action of vertebral artery infusions of angiotensin was studied in the chloralose-anaesthetized greyhound. 2. The cardiovascular response to vertebral artery infusion of angiotensin (0·25–2·0 ng kg −1 min −1 ) was not reduced by clamping the basilar artery between the pons and the pyramidal decussation. There was no response to infusion of angiotensin through a catheter inserted in a rostral direction into the basilar artery above the clamp. The site of action must therefore lie caudal to the pons. 3. Transection of the spinal cord at the first cervical segment did not abolish the response to vertebral artery infusions, which was still mediated by the vagus nerve and abolished by subsequent vagotomy. The site of action must therefore lie rostral to the cervical cord. 4. Local infusions of angiotensin into the small arteries supplying the medulla produced a response similar to that obtained with vertebral artery infusion of angiotensin. 5. These results indicate that the site responsible for these central effects of angiotensin lies in the medulla.