Comprehensive Synthesis of Photoreactive Phenylthiourea Derivatives for the Photoaffinity Labeling
Comprehensive Synthesis of Photoreactive Phenylthiourea Derivatives for the Photoaffinity Labeling
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DOI：
10.1002/slct.201601675
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发表时间：
2017-01-10
期刊：
影响因子：
2.1
通讯作者：
Hashimoto, Makoto
中科院分区：
文献类型：
--
作者：
Ishida, Akiko;Wang, Lei;Hashimoto, Makoto
苯基硫脲（Phenylthiourea，PTU）是一种生物活性物质，是酪氨酸酶的可逆抑制剂.酪氨酸酶在酪氨酸代谢中起重要作用，维持皮肤在阳光照射下的稳态，形成黑色素。PTU的光亲和标记试剂的合成将是酪氨酸酶功能分析的一个有吸引力的课题。
Phenylthiourea (PTU) is well known as bioactive compound and one of the reversible inhibitors for tyrosinase. Tyrosinase plays very important roles for tyrosine metabolisms to maintain the skin homeostasis from sunlight with forming melanin. Synthesis of photoaffinity label reagents of PTU will be attractive thesis to elucidate functional analysis for tyrosinase.